Impact of p53 arg72pro snp on breast cancer risk in north indian population

Naseem Akhter; Sajad A. Dar; Shilpi Chattopadhyay; Shafiul Haque; Razique Anwer; Mohd Wahid; Arshad Jawed; Mohtashim Lohani; Raju K. Mandal; N. K. Shukla; Yasir Abdul; Syed Akhtar Husain

doi:10.2174/1389202919666171205104137

Impact of p53 arg72pro snp on breast cancer risk in north indian population

Naseem Akhter
, Sajad A. Dar
, Shilpi Chattopadhyay
, Shafiul Haque
, Razique Anwer
, Mohd Wahid
, Arshad Jawed
, Mohtashim Lohani
, Raju K. Mandal
, N. K. Shukla
, Yasir Abdul
, Syed Akhtar Husain

Al Baha University
Jamia Millia Islamia
Jazan University
Al-Imam Muhammad Ibn Saud Islamic University
Integral University
All India Institute of Medical Sciences, New Delhi
Augusta University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: Genetic changes in p53 gene contribute to breast cancer susceptibility. Objective and Methods: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence. Conclusion: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.

Original language	English
Pages (from-to)	395-410
Number of pages	16
Journal	Current Genomics
Volume	19
Issue number	5
DOIs	https://doi.org/10.2174/1389202919666171205104137
State	Published - 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Case-control
Indian populations
Meta-analysis
P53 Arg72Pro polymorphism
P53 codon72 SNP

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10.2174/1389202919666171205104137

Cite this

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title = "Impact of p53 arg72pro snp on breast cancer risk in north indian population",

abstract = "Background: Genetic changes in p53 gene contribute to breast cancer susceptibility. Objective and Methods: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence. Conclusion: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.",

keywords = "Breast cancer, Case-control, Indian populations, Meta-analysis, P53 Arg72Pro polymorphism, P53 codon72 SNP",

author = "Naseem Akhter and Dar, \{Sajad A.\} and Shilpi Chattopadhyay and Shafiul Haque and Razique Anwer and Mohd Wahid and Arshad Jawed and Mohtashim Lohani and Mandal, \{Raju K.\} and Shukla, \{N. K.\} and Yasir Abdul and Husain, \{Syed Akhtar\}",

note = "Publisher Copyright: {\textcopyright} 2018 Bentham Science Publishers.",

year = "2018",

doi = "10.2174/1389202919666171205104137",

language = "English",

volume = "19",

pages = "395--410",

journal = "Current Genomics",

issn = "1389-2029",

publisher = "Bentham Science Publishers",

number = "5",

}

TY - JOUR

T1 - Impact of p53 arg72pro snp on breast cancer risk in north indian population

AU - Akhter, Naseem

AU - Dar, Sajad A.

AU - Chattopadhyay, Shilpi

AU - Haque, Shafiul

AU - Anwer, Razique

AU - Wahid, Mohd

AU - Jawed, Arshad

AU - Lohani, Mohtashim

AU - Mandal, Raju K.

AU - Shukla, N. K.

AU - Abdul, Yasir

AU - Husain, Syed Akhtar

PY - 2018

Y1 - 2018

N2 - Background: Genetic changes in p53 gene contribute to breast cancer susceptibility. Objective and Methods: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence. Conclusion: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.

AB - Background: Genetic changes in p53 gene contribute to breast cancer susceptibility. Objective and Methods: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence. Conclusion: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.

KW - Breast cancer

KW - Case-control

KW - Indian populations

KW - Meta-analysis

KW - P53 Arg72Pro polymorphism

KW - P53 codon72 SNP

UR - https://www.scopus.com/pages/publications/85048960827

U2 - 10.2174/1389202919666171205104137

DO - 10.2174/1389202919666171205104137

M3 - Article

AN - SCOPUS:85048960827

SN - 1389-2029

VL - 19

SP - 395

EP - 410

JO - Current Genomics

JF - Current Genomics

IS - 5

ER -

Impact of p53 arg72pro snp on breast cancer risk in north indian population

Abstract

UN SDGs

Keywords

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