Hyaluronic acid based approaches for wound healing: A comprehensive review

Samay Parmal; Praveen Subbappa; Vaidehi Nikam; Yash Tarwate; Kunika Barhate; Shrutika Wagh; Amol D. Gholap; Kamal Dua; Sachin Kumar Singh; Dhaivat Parikh; Mushtaque Shaikh; Tamanna K. Khan; Amarjitsing Rajput

doi:10.1016/j.ijbiomac.2025.141625

Hyaluronic acid based approaches for wound healing: A comprehensive review

Samay Parmal
, Praveen Subbappa
, Vaidehi Nikam
, Yash Tarwate
, Kunika Barhate
, Shrutika Wagh
, Amol D. Gholap
, Kamal Dua
, Sachin Kumar Singh
, Dhaivat Parikh
, Mushtaque Shaikh
, Tamanna K. Khan
, Amarjitsing Rajput

Bharati Vidyapeeth University
Inc.
St. John Institute of Pharmacy and Research
Amrutvahini College of Pharmacy
University of Technology Sydney
Lovely Professional University
Sunway University
Nirma University
University of Mumbai
Guru Nanak Khalsa College of Art Science and Commerce (Autonomus)

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Wound healing is a natural, however complex, tissue repair and regeneration mechanism. Understanding the cascade of biological events associated with wound healing facilitates scientists in designing topical skin formulations with enhanced therapeutic outcomes. In recent years, several innovative approaches have been utilized to treat wounds. Hyaluronic acid (HA)-based formulations have shown promising results. The current manuscript provides a systematic review of various aspects of HA, including its structure, synthesis, mechanism involved in wound healing, and various formulations developed using HA to treat wounds. Covered are innovative treatment strategies explicitly emphasizing nanocarrier-based approaches. Various patents wherein HA has been used to treat wounds are also summarized with the help of a Google patent search. Diving deep, clinical perspectives, toxicity aspects, and application of computational chemistry in HA research are also discussed.

Original language	English
Article number	141625
Journal	International Journal of Biological Macromolecules
Volume	306
DOIs	https://doi.org/10.1016/j.ijbiomac.2025.141625
State	Published - May 2025
Externally published	Yes

Keywords

Hyaluronic acid
Toxicity
Wound healing

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10.1016/j.ijbiomac.2025.141625

Cite this

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title = "Hyaluronic acid based approaches for wound healing: A comprehensive review",

abstract = "Wound healing is a natural, however complex, tissue repair and regeneration mechanism. Understanding the cascade of biological events associated with wound healing facilitates scientists in designing topical skin formulations with enhanced therapeutic outcomes. In recent years, several innovative approaches have been utilized to treat wounds. Hyaluronic acid (HA)-based formulations have shown promising results. The current manuscript provides a systematic review of various aspects of HA, including its structure, synthesis, mechanism involved in wound healing, and various formulations developed using HA to treat wounds. Covered are innovative treatment strategies explicitly emphasizing nanocarrier-based approaches. Various patents wherein HA has been used to treat wounds are also summarized with the help of a Google patent search. Diving deep, clinical perspectives, toxicity aspects, and application of computational chemistry in HA research are also discussed.",

keywords = "Hyaluronic acid, Toxicity, Wound healing",

author = "Samay Parmal and Praveen Subbappa and Vaidehi Nikam and Yash Tarwate and Kunika Barhate and Shrutika Wagh and Gholap, \{Amol D.\} and Kamal Dua and Singh, \{Sachin Kumar\} and Dhaivat Parikh and Mushtaque Shaikh and Khan, \{Tamanna K.\} and Amarjitsing Rajput",

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year = "2025",

month = may,

doi = "10.1016/j.ijbiomac.2025.141625",

language = "English",

volume = "306",

journal = "International Journal of Biological Macromolecules",

issn = "0141-8130",

publisher = "Elsevier B.V.",

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T2 - A comprehensive review

AU - Parmal, Samay

AU - Subbappa, Praveen

AU - Nikam, Vaidehi

AU - Tarwate, Yash

AU - Barhate, Kunika

AU - Wagh, Shrutika

AU - Gholap, Amol D.

AU - Dua, Kamal

AU - Singh, Sachin Kumar

AU - Parikh, Dhaivat

AU - Shaikh, Mushtaque

AU - Khan, Tamanna K.

AU - Rajput, Amarjitsing

PY - 2025/5

Y1 - 2025/5

N2 - Wound healing is a natural, however complex, tissue repair and regeneration mechanism. Understanding the cascade of biological events associated with wound healing facilitates scientists in designing topical skin formulations with enhanced therapeutic outcomes. In recent years, several innovative approaches have been utilized to treat wounds. Hyaluronic acid (HA)-based formulations have shown promising results. The current manuscript provides a systematic review of various aspects of HA, including its structure, synthesis, mechanism involved in wound healing, and various formulations developed using HA to treat wounds. Covered are innovative treatment strategies explicitly emphasizing nanocarrier-based approaches. Various patents wherein HA has been used to treat wounds are also summarized with the help of a Google patent search. Diving deep, clinical perspectives, toxicity aspects, and application of computational chemistry in HA research are also discussed.

AB - Wound healing is a natural, however complex, tissue repair and regeneration mechanism. Understanding the cascade of biological events associated with wound healing facilitates scientists in designing topical skin formulations with enhanced therapeutic outcomes. In recent years, several innovative approaches have been utilized to treat wounds. Hyaluronic acid (HA)-based formulations have shown promising results. The current manuscript provides a systematic review of various aspects of HA, including its structure, synthesis, mechanism involved in wound healing, and various formulations developed using HA to treat wounds. Covered are innovative treatment strategies explicitly emphasizing nanocarrier-based approaches. Various patents wherein HA has been used to treat wounds are also summarized with the help of a Google patent search. Diving deep, clinical perspectives, toxicity aspects, and application of computational chemistry in HA research are also discussed.

KW - Hyaluronic acid

KW - Toxicity

KW - Wound healing

UR - https://www.scopus.com/pages/publications/86000352053

U2 - 10.1016/j.ijbiomac.2025.141625

DO - 10.1016/j.ijbiomac.2025.141625

M3 - Review article

C2 - 40049471

AN - SCOPUS:86000352053

SN - 0141-8130

VL - 306

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

M1 - 141625

ER -

Hyaluronic acid based approaches for wound healing: A comprehensive review

Abstract

Keywords

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