Host defence peptides in diabetes mellitus type 2 patients with periodontal disease. A systematic review

Muhammad Saad Shaikh; Muhammad Sohail Zafar; Farhan Saleem; Ahmad Alnazzawi; Mohid Abrar Lone; Syed Jawad Ali Bukhari; Zohaib Khurshid

doi:10.3390/diagnostics11122210

Host defence peptides in diabetes mellitus type 2 patients with periodontal disease. A systematic review

Muhammad Saad Shaikh
, Muhammad Sohail Zafar
, Farhan Saleem
, Ahmad Alnazzawi
, Mohid Abrar Lone
, Syed Jawad Ali Bukhari
, Zohaib Khurshid

Jinnah Sindh Medical University
Taibah University
Riphah International University
Edith Cowan University
University of Toronto
King Faisal University

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

The aim of the study was to critically assess and review the latest evidence relating the associations between host defence peptides (HDPs), periodontal diseases (PD) and diabetes mellitus type 2 (DM2). To explore studies on HDPs, periodontal disease, and DM2, researchers utilised specific key phrases to search the electronic databases PubMed (National Library of Medicine), Embase (Ovid), Medline (EBSCO), and Dentistry and Oral Sciences (EBSCO). Quality assessment was conducted by means of the Newcastle Ottawa scale and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Following a thorough screening process, a total of 12 papers (4 case‐control, 6 cross‐sectional, 1 animal, and 1 in vitro) fulfilled the selection criteria and were included. The majority of research found that HDPs were upregulated in DM2 patients with PD. Three investigations, however, found that HDPs were downregulated in DM2 patients with PD. HDPs play a part in the pathophysiology of PD and DM2. Nonetheless, more human, animal and laboratory investigations are needed to fully understand validation of the link, as the evidence is limited. Understanding HDPs as common moderators is critical, aimed at unlocking their potential as therapeutic and diagnostic agents.

Original language	English
Article number	2210
Journal	Diagnostics
Volume	11
Issue number	12
DOIs	https://doi.org/10.3390/diagnostics11122210
State	Published - Dec 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antimicrobial peptides
Diabetes mellitus
Periodontal disease
Risk factor

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10.3390/diagnostics11122210

Cite this

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title = "Host defence peptides in diabetes mellitus type 2 patients with periodontal disease. A systematic review",

abstract = "The aim of the study was to critically assess and review the latest evidence relating the associations between host defence peptides (HDPs), periodontal diseases (PD) and diabetes mellitus type 2 (DM2). To explore studies on HDPs, periodontal disease, and DM2, researchers utilised specific key phrases to search the electronic databases PubMed (National Library of Medicine), Embase (Ovid), Medline (EBSCO), and Dentistry and Oral Sciences (EBSCO). Quality assessment was conducted by means of the Newcastle Ottawa scale and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Following a thorough screening process, a total of 12 papers (4 case‐control, 6 cross‐sectional, 1 animal, and 1 in vitro) fulfilled the selection criteria and were included. The majority of research found that HDPs were upregulated in DM2 patients with PD. Three investigations, however, found that HDPs were downregulated in DM2 patients with PD. HDPs play a part in the pathophysiology of PD and DM2. Nonetheless, more human, animal and laboratory investigations are needed to fully understand validation of the link, as the evidence is limited. Understanding HDPs as common moderators is critical, aimed at unlocking their potential as therapeutic and diagnostic agents.",

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doi = "10.3390/diagnostics11122210",

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AU - Shaikh, Muhammad Saad

AU - Zafar, Muhammad Sohail

AU - Saleem, Farhan

AU - Alnazzawi, Ahmad

AU - Lone, Mohid Abrar

AU - Bukhari, Syed Jawad Ali

AU - Khurshid, Zohaib

PY - 2021/12

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N2 - The aim of the study was to critically assess and review the latest evidence relating the associations between host defence peptides (HDPs), periodontal diseases (PD) and diabetes mellitus type 2 (DM2). To explore studies on HDPs, periodontal disease, and DM2, researchers utilised specific key phrases to search the electronic databases PubMed (National Library of Medicine), Embase (Ovid), Medline (EBSCO), and Dentistry and Oral Sciences (EBSCO). Quality assessment was conducted by means of the Newcastle Ottawa scale and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Following a thorough screening process, a total of 12 papers (4 case‐control, 6 cross‐sectional, 1 animal, and 1 in vitro) fulfilled the selection criteria and were included. The majority of research found that HDPs were upregulated in DM2 patients with PD. Three investigations, however, found that HDPs were downregulated in DM2 patients with PD. HDPs play a part in the pathophysiology of PD and DM2. Nonetheless, more human, animal and laboratory investigations are needed to fully understand validation of the link, as the evidence is limited. Understanding HDPs as common moderators is critical, aimed at unlocking their potential as therapeutic and diagnostic agents.

AB - The aim of the study was to critically assess and review the latest evidence relating the associations between host defence peptides (HDPs), periodontal diseases (PD) and diabetes mellitus type 2 (DM2). To explore studies on HDPs, periodontal disease, and DM2, researchers utilised specific key phrases to search the electronic databases PubMed (National Library of Medicine), Embase (Ovid), Medline (EBSCO), and Dentistry and Oral Sciences (EBSCO). Quality assessment was conducted by means of the Newcastle Ottawa scale and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Following a thorough screening process, a total of 12 papers (4 case‐control, 6 cross‐sectional, 1 animal, and 1 in vitro) fulfilled the selection criteria and were included. The majority of research found that HDPs were upregulated in DM2 patients with PD. Three investigations, however, found that HDPs were downregulated in DM2 patients with PD. HDPs play a part in the pathophysiology of PD and DM2. Nonetheless, more human, animal and laboratory investigations are needed to fully understand validation of the link, as the evidence is limited. Understanding HDPs as common moderators is critical, aimed at unlocking their potential as therapeutic and diagnostic agents.

KW - Antimicrobial peptides

KW - Diabetes mellitus

KW - Periodontal disease

KW - Risk factor

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DO - 10.3390/diagnostics11122210

M3 - Review article

AN - SCOPUS:85120179949

SN - 2075-4418

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JO - Diagnostics

JF - Diagnostics

IS - 12

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ER -

Host defence peptides in diabetes mellitus type 2 patients with periodontal disease. A systematic review

Abstract

UN SDGs

Keywords

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