Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases

Navneet Singh; Sukriti Vishwas; Amandeep Kaur; Harmanpreet Kaur; Violina Kakoty; Rubiya Khursheed; M. V.N.L. Chaitanya; Molakpogu Ravindra Babu; Ankit Awasthi; Leander corrie; Vancha Harish; Palakurthi Yanadaiah; Saurabh Gupta; Amany A. Sayed; Amr El-Sayed; Iftikhar Ali; Osama A. Kensara; Nehmat Ghaboura; Gaurav Gupta; Ali M. Dou; Mohammad Algahtani; Attalla F. El-kott; Kamal Dua; Sachin Kumar Singh; Mohamed M. Abdel-Daim

doi:10.1016/j.biopha.2023.115512

Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases

Navneet Singh
, Sukriti Vishwas
, Amandeep Kaur
, Harmanpreet Kaur
, Violina Kakoty
, Rubiya Khursheed
, M. V.N.L. Chaitanya
, Molakpogu Ravindra Babu
, Ankit Awasthi
, Leander corrie
, Vancha Harish
, Palakurthi Yanadaiah
, Saurabh Gupta
, Amany A. Sayed
, Amr El-Sayed
, Iftikhar Ali
, Osama A. Kensara
, Nehmat Ghaboura
, Gaurav Gupta
, Ali M. Dou

Mohammad Algahtani, Attalla F. El-kott, Kamal Dua, Sachin Kumar Singh, Mohamed M. Abdel-Daim

Lovely Professional University
Punjab Technical University
Chameli Devi Institute of Pharmacy
Cairo University
Faculty of Veterinary Medicine
Stony Brook University
Umm Al-Qura University
Batterjee Medical College
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)
Graphic Era Hill University
Suresh Gyan Vihar University
Security Forces Hospital Program Riyadh
Security Forces Hospital - Makkah
King Khalid University
Damanhour University
University of Technology Sydney
Uttaranchal University
Faculty of Veterinary Medicine

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Sesamol is a lignan of sesame seeds and a natural phenolic molecule that has emerged as a useful medical agent. Sesamol is a non-toxic phytoconstituent, which exerts certain valuable effects in the management of cancer, diabetes, cardiovascular diseases, neurodegenerative diseases (NDs), etc. Sesamol is known to depict its neuroprotective role by various mechanisms, such as metabolic regulators, action on oxidative stress, neuroinflammation, etc. However, its poor oral bioavailability, rapid excretion (as conjugates), and susceptibility to gastric irritation/toxicity (particularly in rats' forestomach) may restrict its effectiveness. To overcome the associated limitations, novel drug delivery system-based formulations of sesamol are emerging and being researched extensively. These can conjugate with sesamol and enhance the bioavailability and solubility of free sesamol, along with delivery at the target site. In this review, we have summarized various research works highlighting the role of sesamol on various NDs, including Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Parkinson's disease. Moreover, the formulation strategies and neuroprotective role of sesamol-based nano-formulations have also been discussed.

Original language	English
Article number	115512
Journal	Biomedicine and Pharmacotherapy
Volume	167
DOIs	https://doi.org/10.1016/j.biopha.2023.115512
State	Published - Nov 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bioavailability
Nanoformulations
Neurodegenerative diseases
Neuroprotective effects
Sesamol

Access to Document

10.1016/j.biopha.2023.115512

Cite this

Singh, N., Vishwas, S., Kaur, A., Kaur, H., Kakoty, V., Khursheed, R., Chaitanya, M. V. N. L., Babu, M. R., Awasthi, A., corrie, L., Harish, V., Yanadaiah, P., Gupta, S., Sayed, A. A., El-Sayed, A., Ali, I., Kensara, O. A., Ghaboura, N., Gupta, G., ... Abdel-Daim, M. M. (2023). Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases. Biomedicine and Pharmacotherapy, 167, Article 115512. https://doi.org/10.1016/j.biopha.2023.115512

@article{cf968e8397f04590b85201288bcd6239,

title = "Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases",

abstract = "Sesamol is a lignan of sesame seeds and a natural phenolic molecule that has emerged as a useful medical agent. Sesamol is a non-toxic phytoconstituent, which exerts certain valuable effects in the management of cancer, diabetes, cardiovascular diseases, neurodegenerative diseases (NDs), etc. Sesamol is known to depict its neuroprotective role by various mechanisms, such as metabolic regulators, action on oxidative stress, neuroinflammation, etc. However, its poor oral bioavailability, rapid excretion (as conjugates), and susceptibility to gastric irritation/toxicity (particularly in rats' forestomach) may restrict its effectiveness. To overcome the associated limitations, novel drug delivery system-based formulations of sesamol are emerging and being researched extensively. These can conjugate with sesamol and enhance the bioavailability and solubility of free sesamol, along with delivery at the target site. In this review, we have summarized various research works highlighting the role of sesamol on various NDs, including Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Parkinson's disease. Moreover, the formulation strategies and neuroprotective role of sesamol-based nano-formulations have also been discussed.",

keywords = "Bioavailability, Nanoformulations, Neurodegenerative diseases, Neuroprotective effects, Sesamol",

author = "Navneet Singh and Sukriti Vishwas and Amandeep Kaur and Harmanpreet Kaur and Violina Kakoty and Rubiya Khursheed and Chaitanya, \{M. V.N.L.\} and Babu, \{Molakpogu Ravindra\} and Ankit Awasthi and Leander corrie and Vancha Harish and Palakurthi Yanadaiah and Saurabh Gupta and Sayed, \{Amany A.\} and Amr El-Sayed and Iftikhar Ali and Kensara, \{Osama A.\} and Nehmat Ghaboura and Gaurav Gupta and Dou, \{Ali M.\} and Mohammad Algahtani and El-kott, \{Attalla F.\} and Kamal Dua and Singh, \{Sachin Kumar\} and Abdel-Daim, \{Mohamed M.\}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = nov,

doi = "10.1016/j.biopha.2023.115512",

language = "English",

volume = "167",

journal = "Biomedicine and Pharmacotherapy",

issn = "0753-3322",

publisher = "Elsevier Masson s.r.l.",

}

Singh, N, Vishwas, S, Kaur, A, Kaur, H, Kakoty, V, Khursheed, R, Chaitanya, MVNL, Babu, MR, Awasthi, A, corrie, L, Harish, V, Yanadaiah, P, Gupta, S, Sayed, AA, El-Sayed, A, Ali, I, Kensara, OA, Ghaboura, N, Gupta, G, Dou, AM, Algahtani, M, El-kott, AF, Dua, K, Singh, SK & Abdel-Daim, MM 2023, 'Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases', Biomedicine and Pharmacotherapy, vol. 167, 115512. https://doi.org/10.1016/j.biopha.2023.115512

TY - JOUR

T1 - Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases

AU - Singh, Navneet

AU - Vishwas, Sukriti

AU - Kaur, Amandeep

AU - Kaur, Harmanpreet

AU - Kakoty, Violina

AU - Khursheed, Rubiya

AU - Chaitanya, M. V.N.L.

AU - Babu, Molakpogu Ravindra

AU - Awasthi, Ankit

AU - corrie, Leander

AU - Harish, Vancha

AU - Yanadaiah, Palakurthi

AU - Gupta, Saurabh

AU - Sayed, Amany A.

AU - El-Sayed, Amr

AU - Ali, Iftikhar

AU - Kensara, Osama A.

AU - Ghaboura, Nehmat

AU - Gupta, Gaurav

AU - Dou, Ali M.

AU - Algahtani, Mohammad

AU - El-kott, Attalla F.

AU - Dua, Kamal

AU - Singh, Sachin Kumar

AU - Abdel-Daim, Mohamed M.

PY - 2023/11

Y1 - 2023/11

N2 - Sesamol is a lignan of sesame seeds and a natural phenolic molecule that has emerged as a useful medical agent. Sesamol is a non-toxic phytoconstituent, which exerts certain valuable effects in the management of cancer, diabetes, cardiovascular diseases, neurodegenerative diseases (NDs), etc. Sesamol is known to depict its neuroprotective role by various mechanisms, such as metabolic regulators, action on oxidative stress, neuroinflammation, etc. However, its poor oral bioavailability, rapid excretion (as conjugates), and susceptibility to gastric irritation/toxicity (particularly in rats' forestomach) may restrict its effectiveness. To overcome the associated limitations, novel drug delivery system-based formulations of sesamol are emerging and being researched extensively. These can conjugate with sesamol and enhance the bioavailability and solubility of free sesamol, along with delivery at the target site. In this review, we have summarized various research works highlighting the role of sesamol on various NDs, including Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Parkinson's disease. Moreover, the formulation strategies and neuroprotective role of sesamol-based nano-formulations have also been discussed.

AB - Sesamol is a lignan of sesame seeds and a natural phenolic molecule that has emerged as a useful medical agent. Sesamol is a non-toxic phytoconstituent, which exerts certain valuable effects in the management of cancer, diabetes, cardiovascular diseases, neurodegenerative diseases (NDs), etc. Sesamol is known to depict its neuroprotective role by various mechanisms, such as metabolic regulators, action on oxidative stress, neuroinflammation, etc. However, its poor oral bioavailability, rapid excretion (as conjugates), and susceptibility to gastric irritation/toxicity (particularly in rats' forestomach) may restrict its effectiveness. To overcome the associated limitations, novel drug delivery system-based formulations of sesamol are emerging and being researched extensively. These can conjugate with sesamol and enhance the bioavailability and solubility of free sesamol, along with delivery at the target site. In this review, we have summarized various research works highlighting the role of sesamol on various NDs, including Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Parkinson's disease. Moreover, the formulation strategies and neuroprotective role of sesamol-based nano-formulations have also been discussed.

KW - Bioavailability

KW - Nanoformulations

KW - Neurodegenerative diseases

KW - Neuroprotective effects

KW - Sesamol

UR - https://www.scopus.com/pages/publications/85171661921

U2 - 10.1016/j.biopha.2023.115512

DO - 10.1016/j.biopha.2023.115512

M3 - Review article

C2 - 37725878

AN - SCOPUS:85171661921

SN - 0753-3322

VL - 167

JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

M1 - 115512

ER -

Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases

Abstract

UN SDGs

Keywords

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