Free radical scavenging activity and cytotoxicity study of fermented oats (Avena sativa)

Veena Sunderam; Sathak Sameer Shaik Mohammed; Yasasve Madhavan; Manojj Dhinakaran; Shobana Sampath; Nirmala Patteswaran; Lakshmi Thangavelu; Ansel Vishal Lawrence

doi:10.26452/ijrps.v11i1.1967

Free radical scavenging activity and cytotoxicity study of fermented oats (Avena sativa)

Veena Sunderam
, Sathak Sameer Shaik Mohammed
, Yasasve Madhavan
, Manojj Dhinakaran
, Shobana Sampath
, Nirmala Patteswaran
, Lakshmi Thangavelu
, Ansel Vishal Lawrence

Anna University
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Oats (Avena sativa) is a cereal crop of utmost significance with rich therapeutic and nutritive value. Bioactive substances like tocopherols, phenolic acids, alkylresorcinols, beta-glucan, and avenanthramides present in Avena sativa significantly contribute towards its medicinal action. The current research study aims to assess the antioxidant and anti-cancer efficiency of fermented (FO) and non-fermented (NFO) samples of Avena sativa. In vitro anticancer studies on oats were assessed using colon malignant growth cell lines (HT29) by MTT assay. In vitro studies revealed that fermented and non-fermented oats displayed higher antioxidant activity, having a corresponding IC₅₀ value of 201.03 µL and 236.46 µL, respectively. The cancer cell death percentage at 250 µg/mL concentration ranged between 58.19% and 51.85%, respectively.

Original language	English
Pages (from-to)	1259-1262
Number of pages	4
Journal	International Journal of Research in Pharmaceutical Sciences
Volume	11
Issue number	1
DOIs	https://doi.org/10.26452/ijrps.v11i1.1967
State	Published - 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-cancer
Anti-oxidant
Avena sativa
In vitro studies
Oats

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10.26452/ijrps.v11i1.1967

Cite this

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title = "Free radical scavenging activity and cytotoxicity study of fermented oats (Avena sativa)",

abstract = "Oats (Avena sativa) is a cereal crop of utmost significance with rich therapeutic and nutritive value. Bioactive substances like tocopherols, phenolic acids, alkylresorcinols, beta-glucan, and avenanthramides present in Avena sativa significantly contribute towards its medicinal action. The current research study aims to assess the antioxidant and anti-cancer efficiency of fermented (FO) and non-fermented (NFO) samples of Avena sativa. In vitro anticancer studies on oats were assessed using colon malignant growth cell lines (HT29) by MTT assay. In vitro studies revealed that fermented and non-fermented oats displayed higher antioxidant activity, having a corresponding IC50 value of 201.03 µL and 236.46 µL, respectively. The cancer cell death percentage at 250 µg/mL concentration ranged between 58.19\% and 51.85\%, respectively.",

keywords = "Anti-cancer, Anti-oxidant, Avena sativa, In vitro studies, Oats",

author = "Veena Sunderam and Mohammed, \{Sathak Sameer Shaik\} and Yasasve Madhavan and Manojj Dhinakaran and Shobana Sampath and Nirmala Patteswaran and Lakshmi Thangavelu and Lawrence, \{Ansel Vishal\}",

year = "2020",

doi = "10.26452/ijrps.v11i1.1967",

language = "English",

volume = "11",

pages = "1259--1262",

journal = "International Journal of Research in Pharmaceutical Sciences",

issn = "0975-7538",

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TY - JOUR

T1 - Free radical scavenging activity and cytotoxicity study of fermented oats (Avena sativa)

AU - Sunderam, Veena

AU - Mohammed, Sathak Sameer Shaik

AU - Madhavan, Yasasve

AU - Dhinakaran, Manojj

AU - Sampath, Shobana

AU - Patteswaran, Nirmala

AU - Thangavelu, Lakshmi

AU - Lawrence, Ansel Vishal

PY - 2020

Y1 - 2020

N2 - Oats (Avena sativa) is a cereal crop of utmost significance with rich therapeutic and nutritive value. Bioactive substances like tocopherols, phenolic acids, alkylresorcinols, beta-glucan, and avenanthramides present in Avena sativa significantly contribute towards its medicinal action. The current research study aims to assess the antioxidant and anti-cancer efficiency of fermented (FO) and non-fermented (NFO) samples of Avena sativa. In vitro anticancer studies on oats were assessed using colon malignant growth cell lines (HT29) by MTT assay. In vitro studies revealed that fermented and non-fermented oats displayed higher antioxidant activity, having a corresponding IC50 value of 201.03 µL and 236.46 µL, respectively. The cancer cell death percentage at 250 µg/mL concentration ranged between 58.19% and 51.85%, respectively.

AB - Oats (Avena sativa) is a cereal crop of utmost significance with rich therapeutic and nutritive value. Bioactive substances like tocopherols, phenolic acids, alkylresorcinols, beta-glucan, and avenanthramides present in Avena sativa significantly contribute towards its medicinal action. The current research study aims to assess the antioxidant and anti-cancer efficiency of fermented (FO) and non-fermented (NFO) samples of Avena sativa. In vitro anticancer studies on oats were assessed using colon malignant growth cell lines (HT29) by MTT assay. In vitro studies revealed that fermented and non-fermented oats displayed higher antioxidant activity, having a corresponding IC50 value of 201.03 µL and 236.46 µL, respectively. The cancer cell death percentage at 250 µg/mL concentration ranged between 58.19% and 51.85%, respectively.

KW - Anti-cancer

KW - Anti-oxidant

KW - Avena sativa

KW - In vitro studies

KW - Oats

UR - https://www.scopus.com/pages/publications/85099455346

U2 - 10.26452/ijrps.v11i1.1967

DO - 10.26452/ijrps.v11i1.1967

M3 - Article

AN - SCOPUS:85099455346

SN - 0975-7538

VL - 11

SP - 1259

EP - 1262

JO - International Journal of Research in Pharmaceutical Sciences

JF - International Journal of Research in Pharmaceutical Sciences

IS - 1

ER -

Free radical scavenging activity and cytotoxicity study of fermented oats (Avena sativa)

Abstract

UN SDGs

Keywords

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