Formulation Optimization and Design of SNEDDS

The intended bioavailability of numerous newly approved therapeutics is further impeded due to their poor water solubility. The inability of many medications to dissolve in water creates major obstacles to the development of innovative drug delivery methods and the achievement of desired results. Self-nanoemulsifying drug delivery systems (SNEDDS) have been identified as an effective way of delivering drugs that are hydrophobic, with the goal of enhancing their bioavailability. The SNEDDS formulation can be optimized via diverse designs of experiments. Moreover, the compositions of SNEDDS influence their different properties. This chapter discusses the mechanisms of action of SNEDDS and diverse formulation components. Additionally, the importance of optimization SNEDDS using various designs of the experiment is also briefed. Further, the advances in SNEDDS and different aspects of SNEDDS characterization are covered.