Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation

Dinesh Kumar Chellappan; Neoh Jia Yee; Bhalqish Jeet Kaur Ambar Jeet Singh; Jithendra Panneerselvam; Thiagarajan Madheswaran; Jestin Chellian; Saurabh Satija; Meenu Mehta; Monica Gulati; Gaurav Gupta; Kamal Dua

doi:10.4155/tde-2019-0019

Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation

Dinesh Kumar Chellappan
, Neoh Jia Yee
, Bhalqish Jeet Kaur Ambar Jeet Singh
, Jithendra Panneerselvam
, Thiagarajan Madheswaran
, Jestin Chellian
, Saurabh Satija
, Meenu Mehta
, Monica Gulati
, Gaurav Gupta
, Kamal Dua

International Medical University
Lovely Professional University
Suresh Gyan Vihar University
University of Technology Sydney
University of Newcastle

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Aim: Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Methods: Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. Results: The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. Conclusion: The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.

Original language	English
Pages (from-to)	281-293
Number of pages	13
Journal	Therapeutic Delivery
Volume	10
Issue number	5
DOIs	https://doi.org/10.4155/tde-2019-0019
State	Published - 2019
Externally published	Yes

Keywords

chitosan
glibenclamide
quercetin
skin-permeating nanogel

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10.4155/tde-2019-0019

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title = "Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation",

abstract = "Aim: Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Methods: Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. Results: The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. Conclusion: The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.",

keywords = "chitosan, glibenclamide, quercetin, skin-permeating nanogel",

author = "Chellappan, \{Dinesh Kumar\} and Yee, \{Neoh Jia\} and \{Kaur Ambar Jeet Singh\}, \{Bhalqish Jeet\} and Jithendra Panneerselvam and Thiagarajan Madheswaran and Jestin Chellian and Saurabh Satija and Meenu Mehta and Monica Gulati and Gaurav Gupta and Kamal Dua",

note = "Publisher Copyright: {\textcopyright} 2019 Newlands Press.",

year = "2019",

doi = "10.4155/tde-2019-0019",

language = "English",

volume = "10",

pages = "281--293",

journal = "Therapeutic Delivery",

issn = "2041-5990",

publisher = "Taylor and Francis Ltd.",

number = "5",

}

TY - JOUR

T1 - Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation

AU - Chellappan, Dinesh Kumar

AU - Yee, Neoh Jia

AU - Kaur Ambar Jeet Singh, Bhalqish Jeet

AU - Panneerselvam, Jithendra

AU - Madheswaran, Thiagarajan

AU - Chellian, Jestin

AU - Satija, Saurabh

AU - Mehta, Meenu

AU - Gulati, Monica

AU - Gupta, Gaurav

AU - Dua, Kamal

PY - 2019

Y1 - 2019

N2 - Aim: Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Methods: Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. Results: The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. Conclusion: The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.

AB - Aim: Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Methods: Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. Results: The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. Conclusion: The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.

KW - chitosan

KW - glibenclamide

KW - quercetin

KW - skin-permeating nanogel

UR - https://www.scopus.com/pages/publications/85065964611

U2 - 10.4155/tde-2019-0019

DO - 10.4155/tde-2019-0019

M3 - Article

C2 - 31094299

AN - SCOPUS:85065964611

SN - 2041-5990

VL - 10

SP - 281

EP - 293

JO - Therapeutic Delivery

JF - Therapeutic Delivery

IS - 5

ER -

Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation

Abstract

Keywords

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