Exploration of the Potentials of Silymarin in Atopic Dermatitis with In Silico Evidence: An Overview

The recurrent and remitting skin disorder known as atopic dermatitis, or eczema, is caused by immunological dysregulation, environmental variables, and mutations in the epidermal gene that damage the epidermis and cause extremely irritating skin sores. In developed countries, it has been estimated to impact 2% to 10% of adults and 10% to 30% of children. Numerous flavonoid compounds have shown promising results in the treatment of atopic dermatitis, and plant-based flavonoids with their antioxidant, anti-inflammatory, anti-proliferative, and chemoprotective qualities have been investigated. This study offers a comprehensive review of silymarin's function in atopic dermatitis based on the published research that is accessible through the scientific database. In order to find relevant information about the effects of silymarin in atopic dermatitis, 2,352 articles were evaluated using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) criteria, which are designed for systematic review authoring. Results: The present work centres on a comprehensive meta-analysis of the scientific literature and the latest available research updates. An effort has been made to compile the pertinent data about the pharmacological and phytochemical features of silymarin, a flavonoid molecule, in the study of skin disorders. In support of the material analyzed in the literature, we conducted an in-silico investigation, the findings of which are discussed in this article.