Evaluation of the anti-inflammatory properties of telmesteine on inflammation-associated skin diseases

Xuetao Xu; Danying Huang; Wenfeng Liu; Zhaojun Sheng; Kanyi Liang; Dongli Li; Denggao Zhao; Yanyan Ma; Kun Zhang; Tasawar Hayat; Njud S. Alharbi; Weikuai Li

doi:10.1039/c7ra01111c

Evaluation of the anti-inflammatory properties of telmesteine on inflammation-associated skin diseases

Xuetao Xu
, Danying Huang
, Wenfeng Liu
, Zhaojun Sheng
, Kanyi Liang
, Dongli Li
, Denggao Zhao
, Yanyan Ma
, Kun Zhang
, Tasawar Hayat
, Njud S. Alharbi
, Weikuai Li

Wuyi University
International Healthcare Innovation Institute (Jiangmen)
Université du Maine
Quaid-I-Azam University
King Abdulaziz University
Faculty of Sciences, King Abdulaziz University
Suzhou Pharmpower Topical Research Labratory Co. Ltd.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Telmesteine, a useful agent for respiratory tract disorders, has been reported to be a critical active ingredient in topical compositions for dermatitis. The present study was designed to elucidate the in vitro and in vivo anti-inflammatory properties of telmesteine. LPS-induced NO production in RAW264.7 cells was significantly decreased after telmesteine treatment. TPA-induced skin inflammation as assessed by skin edema and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) was significantly decreased after telmesteine topical treatment. Further analysis results demonstrated that the anti-inflammation properties of telmesteine were associated with its ability to inhibit activation of nuclear factor kappa-κB (NF-κB) by blocking phosphoinositide 3-kinase/protein kinase B (PI3K/Akt)/IκB kinase (IKK) activities.

Original language	English
Pages (from-to)	34699-34704
Number of pages	6
Journal	RSC Advances
Volume	7
Issue number	55
DOIs	https://doi.org/10.1039/c7ra01111c
State	Published - 2017
Externally published	Yes

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10.1039/c7ra01111c

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title = "Evaluation of the anti-inflammatory properties of telmesteine on inflammation-associated skin diseases",

abstract = "Telmesteine, a useful agent for respiratory tract disorders, has been reported to be a critical active ingredient in topical compositions for dermatitis. The present study was designed to elucidate the in vitro and in vivo anti-inflammatory properties of telmesteine. LPS-induced NO production in RAW264.7 cells was significantly decreased after telmesteine treatment. TPA-induced skin inflammation as assessed by skin edema and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) was significantly decreased after telmesteine topical treatment. Further analysis results demonstrated that the anti-inflammation properties of telmesteine were associated with its ability to inhibit activation of nuclear factor kappa-κB (NF-κB) by blocking phosphoinositide 3-kinase/protein kinase B (PI3K/Akt)/IκB kinase (IKK) activities.",

author = "Xuetao Xu and Danying Huang and Wenfeng Liu and Zhaojun Sheng and Kanyi Liang and Dongli Li and Denggao Zhao and Yanyan Ma and Kun Zhang and Tasawar Hayat and Alharbi, \{Njud S.\} and Weikuai Li",

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year = "2017",

doi = "10.1039/c7ra01111c",

language = "English",

volume = "7",

pages = "34699--34704",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Evaluation of the anti-inflammatory properties of telmesteine on inflammation-associated skin diseases

AU - Xu, Xuetao

AU - Huang, Danying

AU - Liu, Wenfeng

AU - Sheng, Zhaojun

AU - Liang, Kanyi

AU - Li, Dongli

AU - Zhao, Denggao

AU - Ma, Yanyan

AU - Zhang, Kun

AU - Hayat, Tasawar

AU - Alharbi, Njud S.

AU - Li, Weikuai

PY - 2017

Y1 - 2017

N2 - Telmesteine, a useful agent for respiratory tract disorders, has been reported to be a critical active ingredient in topical compositions for dermatitis. The present study was designed to elucidate the in vitro and in vivo anti-inflammatory properties of telmesteine. LPS-induced NO production in RAW264.7 cells was significantly decreased after telmesteine treatment. TPA-induced skin inflammation as assessed by skin edema and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) was significantly decreased after telmesteine topical treatment. Further analysis results demonstrated that the anti-inflammation properties of telmesteine were associated with its ability to inhibit activation of nuclear factor kappa-κB (NF-κB) by blocking phosphoinositide 3-kinase/protein kinase B (PI3K/Akt)/IκB kinase (IKK) activities.

AB - Telmesteine, a useful agent for respiratory tract disorders, has been reported to be a critical active ingredient in topical compositions for dermatitis. The present study was designed to elucidate the in vitro and in vivo anti-inflammatory properties of telmesteine. LPS-induced NO production in RAW264.7 cells was significantly decreased after telmesteine treatment. TPA-induced skin inflammation as assessed by skin edema and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) was significantly decreased after telmesteine topical treatment. Further analysis results demonstrated that the anti-inflammation properties of telmesteine were associated with its ability to inhibit activation of nuclear factor kappa-κB (NF-κB) by blocking phosphoinositide 3-kinase/protein kinase B (PI3K/Akt)/IκB kinase (IKK) activities.

UR - https://www.scopus.com/pages/publications/85023750751

U2 - 10.1039/c7ra01111c

DO - 10.1039/c7ra01111c

M3 - Article

AN - SCOPUS:85023750751

SN - 2046-2069

VL - 7

SP - 34699

EP - 34704

JO - RSC Advances

JF - RSC Advances

IS - 55

ER -

Evaluation of the anti-inflammatory properties of telmesteine on inflammation-associated skin diseases

Abstract

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