Evaluation of anxiolytic activity of embelin isolated from Embelia ribes

Muhammad Afzal; Gaurav Gupta; Imran Kazmi; Mahfoozur Rahman; Gaurav Upadhyay; Kamran Ahmad; Faisal Imam; Mohammad Pravez; Firoz Anwar

doi:10.1016/j.biomag.2012.03.003

Evaluation of anxiolytic activity of embelin isolated from Embelia ribes

Muhammad Afzal
, Gaurav Gupta
, Imran Kazmi
, Mahfoozur Rahman
, Gaurav Upadhyay
, Kamran Ahmad
, Faisal Imam
, Mohammad Pravez
, Firoz Anwar

Siddhartha Institute of Pharmacy
Dreamz College of Pharmacy
Jamia Hamdard University

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The study aimed to evaluate the anxiolytic activity of embelin that was isolated from Embelia ribes. It significantly increased the percentage of time spent and number of entries in open arm in elevated plus-maze apparatus. In light and dark model, embelin produced significant increase in time spent, number of crossing and decrease in the duration of immobility in light box. In open field test, embelin showed significant increase in number of rearing, assisted rearing and number of square crossed. On the basis of result, embelin showed its anxiolytic effect in dose-dependent manner.

Original language	English
Pages (from-to)	45-47
Number of pages	3
Journal	Biomedicine and Aging Pathology
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.biomag.2012.03.003
State	Published - Apr 2012
Externally published	Yes

Keywords

Anxiolytic
Column Chromatography
Embelia ribes
Embelin

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10.1016/j.biomag.2012.03.003

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title = "Evaluation of anxiolytic activity of embelin isolated from Embelia ribes",

abstract = "The study aimed to evaluate the anxiolytic activity of embelin that was isolated from Embelia ribes. It significantly increased the percentage of time spent and number of entries in open arm in elevated plus-maze apparatus. In light and dark model, embelin produced significant increase in time spent, number of crossing and decrease in the duration of immobility in light box. In open field test, embelin showed significant increase in number of rearing, assisted rearing and number of square crossed. On the basis of result, embelin showed its anxiolytic effect in dose-dependent manner.",

keywords = "Anxiolytic, Column Chromatography, Embelia ribes, Embelin",

author = "Muhammad Afzal and Gaurav Gupta and Imran Kazmi and Mahfoozur Rahman and Gaurav Upadhyay and Kamran Ahmad and Faisal Imam and Mohammad Pravez and Firoz Anwar",

year = "2012",

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doi = "10.1016/j.biomag.2012.03.003",

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T1 - Evaluation of anxiolytic activity of embelin isolated from Embelia ribes

AU - Afzal, Muhammad

AU - Gupta, Gaurav

AU - Kazmi, Imran

AU - Rahman, Mahfoozur

AU - Upadhyay, Gaurav

AU - Ahmad, Kamran

AU - Imam, Faisal

AU - Pravez, Mohammad

AU - Anwar, Firoz

PY - 2012/4

Y1 - 2012/4

N2 - The study aimed to evaluate the anxiolytic activity of embelin that was isolated from Embelia ribes. It significantly increased the percentage of time spent and number of entries in open arm in elevated plus-maze apparatus. In light and dark model, embelin produced significant increase in time spent, number of crossing and decrease in the duration of immobility in light box. In open field test, embelin showed significant increase in number of rearing, assisted rearing and number of square crossed. On the basis of result, embelin showed its anxiolytic effect in dose-dependent manner.

AB - The study aimed to evaluate the anxiolytic activity of embelin that was isolated from Embelia ribes. It significantly increased the percentage of time spent and number of entries in open arm in elevated plus-maze apparatus. In light and dark model, embelin produced significant increase in time spent, number of crossing and decrease in the duration of immobility in light box. In open field test, embelin showed significant increase in number of rearing, assisted rearing and number of square crossed. On the basis of result, embelin showed its anxiolytic effect in dose-dependent manner.

KW - Anxiolytic

KW - Column Chromatography

KW - Embelia ribes

KW - Embelin

UR - https://www.scopus.com/pages/publications/84861986846

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DO - 10.1016/j.biomag.2012.03.003

M3 - Article

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SN - 2210-5220

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SP - 45

EP - 47

JO - Biomedicine and Aging Pathology

JF - Biomedicine and Aging Pathology

IS - 2

ER -

Evaluation of anxiolytic activity of embelin isolated from Embelia ribes

Abstract

Keywords

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