TY - JOUR
T1 - Epidemiologic and Clinical Outcomes of Pediatric Renal Tumors in Korea
T2 - A Retrospective Analysis of The Korean Pediatric Hematology and Oncology Group (KPHOG) Data
AU - GBD 2021 Dietary Iron Deficiency Collaborators
AU - Lee, Sooji
AU - Son, Yejun
AU - Hwang, Jiyoung
AU - Kim, Min Seo
AU - Shin, Jae Il
AU - Yon, Dong Keon
AU - Kassebaum, Nicholas J.
AU - Abate, Semagn Mekonnen
AU - Abate, Yohannes Habtegiorgis
AU - Elhafeez, Samar Abd
AU - Abd-Elsalam, Sherief
AU - Abdoun, Meriem
AU - Abdulkader, Rizwan Suliankatchi
AU - Abdullahi, Auwal
AU - Abebe, Mesfin
AU - Abedi, Armita
AU - Abie, Alemwork
AU - Abiodun, Olumide
AU - Aboagye, Richard Gyan
AU - Abolhassani, Hassan
AU - Abouzid, Mohamed
AU - Abreu, Lucas Guimarães
AU - Abualruz, Hasan
AU - Abukhadijah, Hana J.
AU - Aburuz, Salahdein
AU - Abu-Zaid, Ahmed
AU - Adamu, Lawan Hassan
AU - Adane, Mesafint Molla
AU - Addo, Isaac Yeboah
AU - Adegboye, Oyelola A.
AU - Adekanmbi, Victor
AU - Adetunji, Charles Oluwaseun
AU - Adeyeoluwa, Temitayo Esther
AU - Adnani, Qorinah Estiningtyas Sakilah
AU - Adzigbli, Leticia Akua
AU - Afzal, Saira
AU - Agampodi, Suneth Buddhika
AU - Agyemang-Duah, Williams
AU - Ahmad, Aqeel
AU - Ahmad, Muayyad M.
AU - Ahmad, Shahzaib
AU - Ahmad, Tauseef
AU - Ahmed, Ali
AU - Ahmed, Ayman
AU - Ahmed, Haroon
AU - Ahmed, Mehrunnisha Sharif
AU - Ahmed, Syed Anees
AU - Dutta, Sulagna
AU - Shahwan, Moyad Jamal
AU - Shamsi, Anas
N1 - Publisher Copyright:
Copyright © 2023 by the Korean Cancer Association.
PY - 2023/1
Y1 - 2023/1
N2 - Purpose Renal tumors account for approximately 7% of all childhood cancers. These include Wilms tumor (WT), clear cell sarcoma of the kidney (CCSK), malignant rhabdoid tumor of the kidney (MRTK), renal cell carcinoma (RCC), congenital mesoblastic nephroma (CMN) and other rare tumors. We investigated the epidemiology of pediatric renal tumors in Korea. Materials and Methods From January 2001 to December 2015, data of pediatric patients (0-18 years) newly-diagnosed with renal tumors at 26 hospitals were retrospectively analyzed. Results Among 439 patients (male, 240), the most common tumor was WT (n=342, 77.9%), followed by RCC (n=36, 8.2%), CCSK (n=24, 5.5%), MRTK (n=16, 3.6%), CMN (n=12, 2.7%), and others (n=9, 2.1%). Median age at diagnosis was 27.1 months (range, 0 to 225.5 months) and median follow-up duration was 88.5 months (range, 0 to 211.6 months). Overall, 32 patients died, of whom 17, 11, 1, and three died of relapse, progressive disease, second malignant neoplasm, and treatment-related mortality. Five-year overall survival and event-free survival were 97.2% and 84.8% in WT, 90.6% and 82.1% in RCC, 81.1% and 63.6% in CCSK, 60.3% and 56.2% in MRTK, and 100% and 91.7% in CMN, respectively (p < 0.001). Conclusion The pediatric renal tumor types in Korea are similar to those previously reported in other countries. WT accounted for a large proportion and survival was excellent. Non-Wilms renal tumors included a variety of tumors and showed inferior outcome, especially MRTK. Further efforts are necessary to optimize the treatment and analyze the genetic characteristics of pediatric renal tumors in Korea.
AB - Purpose Renal tumors account for approximately 7% of all childhood cancers. These include Wilms tumor (WT), clear cell sarcoma of the kidney (CCSK), malignant rhabdoid tumor of the kidney (MRTK), renal cell carcinoma (RCC), congenital mesoblastic nephroma (CMN) and other rare tumors. We investigated the epidemiology of pediatric renal tumors in Korea. Materials and Methods From January 2001 to December 2015, data of pediatric patients (0-18 years) newly-diagnosed with renal tumors at 26 hospitals were retrospectively analyzed. Results Among 439 patients (male, 240), the most common tumor was WT (n=342, 77.9%), followed by RCC (n=36, 8.2%), CCSK (n=24, 5.5%), MRTK (n=16, 3.6%), CMN (n=12, 2.7%), and others (n=9, 2.1%). Median age at diagnosis was 27.1 months (range, 0 to 225.5 months) and median follow-up duration was 88.5 months (range, 0 to 211.6 months). Overall, 32 patients died, of whom 17, 11, 1, and three died of relapse, progressive disease, second malignant neoplasm, and treatment-related mortality. Five-year overall survival and event-free survival were 97.2% and 84.8% in WT, 90.6% and 82.1% in RCC, 81.1% and 63.6% in CCSK, 60.3% and 56.2% in MRTK, and 100% and 91.7% in CMN, respectively (p < 0.001). Conclusion The pediatric renal tumor types in Korea are similar to those previously reported in other countries. WT accounted for a large proportion and survival was excellent. Non-Wilms renal tumors included a variety of tumors and showed inferior outcome, especially MRTK. Further efforts are necessary to optimize the treatment and analyze the genetic characteristics of pediatric renal tumors in Korea.
UR - https://www.scopus.com/pages/publications/105026873893
U2 - 10.4143/crt.2022.073
DO - 10.4143/crt.2022.073
M3 - Article
C2 - 35952715
AN - SCOPUS:105026873893
SN - 1598-2998
VL - 55
SP - 279
EP - 290
JO - Cancer Research and Treatment
JF - Cancer Research and Treatment
IS - 1
ER -
SDG 3 Good Health and Well-being