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Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms

  • Yinghan Chan
  • , Sin Wi Ng
  • , Joycelin Zhu Xin Tan
  • , Gaurav Gupta
  • , Murtaza M. Tambuwala
  • , Hamid A. Bakshi
  • , Harish Dureja
  • , Kamal Dua
  • , Muhammad Ishaq
  • , Vanni Caruso
  • , Dinesh Kumar Chellappan
  • International Medical University
  • Suresh Gyan Vihar University
  • Ulster University
  • Maharshi Dayanand University
  • University of Technology Sydney
  • University of Newcastle
  • Shoolini University of Biotechnology and Management Sciences
  • University of Tasmania

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Over the years, the attention of researchers in the field of modern drug discovery and development has become further intense on the identification of active compounds from plant sources and traditional remedies, as they exhibit higher therapeutic efficacies and improved toxicological profiles. Among the large diversity of plant extracts that have been discovered and explored for their potential therapeutic benefits, asperuloside, an iridoid glycoside, has been proven to provide promising effects as a therapeutic agent for several diseases. Although, this potent substance exists in several genera, it is primarily found in plants belonging to the genus Eucommia. Recent decades have seen a surge in the research on Asperuloside, making it one of the most studied natural products in the field of medicine and pharmacology. In this review, we have attempted to study the various reported mechanisms of asperuloside that form the basis of its wide spectrum of pharmacological activities.

Original languageEnglish
Article number108911
JournalChemico-Biological Interactions
Volume315
DOIs
StatePublished - 5 Jan 2020
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Anti-Cancer
  • Anti-Obesity
  • Anti-bacterial
  • Anti-inflammatory
  • Asperuloside
  • Laxative

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