Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

Ankur Sharma; Susan Hawthorne; Saurabh Kumar Jha; Niraj Kumar Jha; Dhruv Kumar; Samuel Girgis; Vineet Kumar Goswami; Gaurav Gupta; Sachin Singh; Harish Dureja; Dinesh Kumar Chellappan; Kamal Dua

doi:10.2217/nnm-2021-0066

Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

Ankur Sharma
, Susan Hawthorne
, Saurabh Kumar Jha
, Niraj Kumar Jha
, Dhruv Kumar
, Samuel Girgis
, Vineet Kumar Goswami
, Gaurav Gupta
, Sachin Singh
, Harish Dureja
, Dinesh Kumar Chellappan
, Kamal Dua

Sharda University
Ulster University
Amity University, Noida
University of Sunderland
GD Goenka University
Jaipur National University
Lovely Professional University
Maharshi Dayanand University
International Medical University
University of Technology Sydney

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area.

Original language	English
Pages (from-to)	1763-1773
Number of pages	11
Journal	Nanomedicine
Volume	16
Issue number	20
DOIs	https://doi.org/10.2217/nnm-2021-0066
State	Published - Aug 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

PLGA
anti-metastasis
curcumin
invasion
nanoparticles
solvent evaporation

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10.2217/nnm-2021-0066

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title = "Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells",

abstract = "Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area.",

keywords = "PLGA, anti-metastasis, curcumin, invasion, nanoparticles, solvent evaporation",

author = "Ankur Sharma and Susan Hawthorne and Jha, \{Saurabh Kumar\} and Jha, \{Niraj Kumar\} and Dhruv Kumar and Samuel Girgis and Goswami, \{Vineet Kumar\} and Gaurav Gupta and Sachin Singh and Harish Dureja and Chellappan, \{Dinesh Kumar\} and Kamal Dua",

year = "2021",

month = aug,

doi = "10.2217/nnm-2021-0066",

language = "English",

volume = "16",

pages = "1763--1773",

journal = "Nanomedicine",

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publisher = "Taylor and Francis Ltd.",

number = "20",

}

TY - JOUR

T1 - Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

AU - Sharma, Ankur

AU - Hawthorne, Susan

AU - Jha, Saurabh Kumar

AU - Jha, Niraj Kumar

AU - Kumar, Dhruv

AU - Girgis, Samuel

AU - Goswami, Vineet Kumar

AU - Gupta, Gaurav

AU - Singh, Sachin

AU - Dureja, Harish

AU - Chellappan, Dinesh Kumar

AU - Dua, Kamal

PY - 2021/8

Y1 - 2021/8

N2 - Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area.

AB - Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area.

KW - PLGA

KW - anti-metastasis

KW - curcumin

KW - invasion

KW - nanoparticles

KW - solvent evaporation

UR - https://www.scopus.com/pages/publications/85112197303

U2 - 10.2217/nnm-2021-0066

DO - 10.2217/nnm-2021-0066

M3 - Article

C2 - 34296625

AN - SCOPUS:85112197303

SN - 1743-5889

VL - 16

SP - 1763

EP - 1773

JO - Nanomedicine

JF - Nanomedicine

IS - 20

ER -

Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

Abstract

UN SDGs

Keywords

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