TY - JOUR
T1 - Development and evaluation of fluticasone propionate/cefadroxil-loaded chitosan/PVA nanofibers for enhanced wound healing
AU - Rashid, Saman
AU - Waqas, Muhammad Khurram
AU - Afzal, Muhammad Irfan
AU - Ibrahim, Nihal Abdalla
AU - Amjad, Khadija
AU - Nasir, Bushra
AU - Khan, Abida Kalsoom
AU - Ijaz, Munaza
N1 - Publisher Copyright:
© The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
PY - 2025/1/1
Y1 - 2025/1/1
N2 - Nanotechnology use in advanced wound dressings is massively increasing in the prevention and treatment of bacterial infections with anti-inflammatory effects. This research aimed to prepare nanofibers of fluticasone/cefadroxil loaded in chitosan/polyvinyl alcohol (PVA) (FCCPNFs) by electrospinning. FTIR, XRD, SEM and DSC were performed to analyze the successful drug loading, crystalline and amorphous nature, structural properties and thermal integrity of the nanofibers respectively. In pharmaceutical analysis zeta size and zeta potential, swelling behaviour, antibacterial activity and potential of wound healing were ascertained. FTIR spectra revealed the compatibility between polymers and loaded drugs. XRD exhibited the semi-crystalline nature of cefadroxil monohydrate and the crystalline nature of chitosan, PVA, fluticasone, and CFM. SEM analysis revealed the continuous fibrous network of FCCPNFs. DSC study confirmed the thermal stability of FCCPNFs. The zeta size and zeta potential of FCCPNFs were <300 nm and 21.2 ± 5.37 mV respectively. The swelling study exhibited the exudate absorption capacity of FCCPNFs. A drug release study showed the burst release of the drugs. FCCPNFs exhibited antibacterial activity against Staphylococcus aureus. In vivo and histopathological studies substantiated the rapid wound healing by FCCPNFs compared to negative control (untreated) and positive control (Quench). The chemical and pharmaceutical analysis confirmed the successful synthesis of stable FCCPNFs with good antibacterial potential against Gram-positive bacteria and propitious wound-healing.
AB - Nanotechnology use in advanced wound dressings is massively increasing in the prevention and treatment of bacterial infections with anti-inflammatory effects. This research aimed to prepare nanofibers of fluticasone/cefadroxil loaded in chitosan/polyvinyl alcohol (PVA) (FCCPNFs) by electrospinning. FTIR, XRD, SEM and DSC were performed to analyze the successful drug loading, crystalline and amorphous nature, structural properties and thermal integrity of the nanofibers respectively. In pharmaceutical analysis zeta size and zeta potential, swelling behaviour, antibacterial activity and potential of wound healing were ascertained. FTIR spectra revealed the compatibility between polymers and loaded drugs. XRD exhibited the semi-crystalline nature of cefadroxil monohydrate and the crystalline nature of chitosan, PVA, fluticasone, and CFM. SEM analysis revealed the continuous fibrous network of FCCPNFs. DSC study confirmed the thermal stability of FCCPNFs. The zeta size and zeta potential of FCCPNFs were <300 nm and 21.2 ± 5.37 mV respectively. The swelling study exhibited the exudate absorption capacity of FCCPNFs. A drug release study showed the burst release of the drugs. FCCPNFs exhibited antibacterial activity against Staphylococcus aureus. In vivo and histopathological studies substantiated the rapid wound healing by FCCPNFs compared to negative control (untreated) and positive control (Quench). The chemical and pharmaceutical analysis confirmed the successful synthesis of stable FCCPNFs with good antibacterial potential against Gram-positive bacteria and propitious wound-healing.
KW - PVA
KW - Staphylococcus aureus
KW - cefadroxil
KW - chitosan
KW - electrospinning
KW - fluticasone
UR - https://www.scopus.com/pages/publications/105025525535
U2 - 10.1177/09673911251353265
DO - 10.1177/09673911251353265
M3 - Article
AN - SCOPUS:105025525535
SN - 0967-3911
VL - 33
JO - Polymers and Polymer Composites
JF - Polymers and Polymer Composites
ER -