Determination of ebastine in pharmaceutical formulations by HPLC

S. Prabu; C. Kumar; A. Shirwaikar; Annie Shirwaikar

doi:10.4103/0250-474X.43022

Determination of ebastine in pharmaceutical formulations by HPLC

S. Prabu
, C. Kumar
, A. Shirwaikar
, Annie Shirwaikar

Manipal Academy of Higher Education

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A simple, precise and rapid RP-HPLC method was developed for the determination of ebastine in pharmaceutical formulations. The method was carried out on a Phenomenex RP-C18 column using a mixture of methanol and water (90:10) and detection was done at 262 nm. The linearity range was 5-100 μg/ml. The intra-day and inter-day precision were in the range of 0.22% to 0.49% and 0.24% to 0.73%, respectively.

Original language	English
Pages (from-to)	406-407
Number of pages	2
Journal	Indian Journal of Pharmaceutical Sciences
Volume	70
Issue number	3
DOIs	https://doi.org/10.4103/0250-474X.43022
State	Published - 1 Feb 2008
Externally published	Yes

Keywords

Ebastine
Reverse-phase liquid chromatography
Solid dosage form

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10.4103/0250-474X.43022

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title = "Determination of ebastine in pharmaceutical formulations by HPLC",

abstract = "A simple, precise and rapid RP-HPLC method was developed for the determination of ebastine in pharmaceutical formulations. The method was carried out on a Phenomenex RP-C18 column using a mixture of methanol and water (90:10) and detection was done at 262 nm. The linearity range was 5-100 μg/ml. The intra-day and inter-day precision were in the range of 0.22\% to 0.49\% and 0.24\% to 0.73\%, respectively.",

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AU - Prabu, S.

AU - Kumar, C.

AU - Shirwaikar, A.

AU - Shirwaikar, Annie

PY - 2008/2/1

Y1 - 2008/2/1

N2 - A simple, precise and rapid RP-HPLC method was developed for the determination of ebastine in pharmaceutical formulations. The method was carried out on a Phenomenex RP-C18 column using a mixture of methanol and water (90:10) and detection was done at 262 nm. The linearity range was 5-100 μg/ml. The intra-day and inter-day precision were in the range of 0.22% to 0.49% and 0.24% to 0.73%, respectively.

AB - A simple, precise and rapid RP-HPLC method was developed for the determination of ebastine in pharmaceutical formulations. The method was carried out on a Phenomenex RP-C18 column using a mixture of methanol and water (90:10) and detection was done at 262 nm. The linearity range was 5-100 μg/ml. The intra-day and inter-day precision were in the range of 0.22% to 0.49% and 0.24% to 0.73%, respectively.

KW - Ebastine

KW - Reverse-phase liquid chromatography

KW - Solid dosage form

UR - https://www.scopus.com/pages/publications/52149093063

U2 - 10.4103/0250-474X.43022

DO - 10.4103/0250-474X.43022

M3 - Article

AN - SCOPUS:52149093063

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VL - 70

SP - 406

EP - 407

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

IS - 3

ER -

Determination of ebastine in pharmaceutical formulations by HPLC

Abstract

Keywords

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