Degradability, Biological Properties of PMMA Bioglass towards Regenerative Applications

PMMA borate bioglass thin films have drawn growing interest in regenerative medicine because of their special mix of biodegradability and advantageous biological characteristics. These thin films are built from polymethyl methacrylate (PMMA) matrix mixed with borate bioactive glass, resulting in a synergistic biomaterial platform with enormous potential for tissue engineering and wound healing applications. PMMA's regulated biodegradability enables its slow breakdown and fusion with regenerated tissue, while the borate bioactive glass component releases vital bioactive ions including calcium, silicon, and sodium to support cellular responses and tissue regeneration.In this review, we examine the bioglass thin films made of PMMA and borate and highlight their biological characteristics that are pertinent to regenerative medicine. According to experimental research, over time, these films experience controlled PMMA hydrolysis and the release of bioactive ions, allowing for a synchronized disintegration process that matches the rate of tissue recovery. The thin films also exhibit outstanding cytocompatibility, promoting cell adhesion, proliferation, and differentiation—all essential processes for tissue growth and regeneration.The addition of borate bioactive glass to the thin films improves their bioactivity while also increasing angiogenesis and osteogenesis, which aid in tissue integration and bone and cartilage regeneration. These thin films serve as a link between biomaterials and regenerative medicine, and further study and improvement could lead to the discovery of novel approaches to tackle difficult medical problems and enhance patient outcomes.