Cytotoxicity of inhalable dry powders in A549 human lung cancer cell line

Anita Chvatal; Rami Alzhrani; Amit K. Tiwari; Rita Ambrus; Piroska Szabó-Révész; Sai H.S. Boddu

Cytotoxicity of inhalable dry powders in A549 human lung cancer cell line

Anita Chvatal
, Rami Alzhrani
, Amit K. Tiwari
, Rita Ambrus
, Piroska Szabó-Révész
, Sai H.S. Boddu

University of Szeged
University of Toledo

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The aim of the present work was to study the cytotoxicity of meloxicam potassium (MP) containing dry powder inhalation systems (DPIs) in monolayers of A549 lung epithelial cells, in order to acquire information on its suitability for pulmonary drug delivery. We also characterized the effect of the used excipients (such as aerosolization enhancer additives and polymers) on the cytotoxicity of the formulated DPIs. We reported for the first time the cytotoxicity of MP in comparison with meloxicam (M) and the results showed that no difference in the safety can be determined at 0.01 and 0.1 mg/mL concentrations. The protective effect of L-leucine was observed in some formulations, while the use of poly-vinyl-alcohol (PVA) decreases this advantage. Comparing the two polymers it can be established that the poly-vinyl-pirrolidon (PVP) is less toxic than the PVA in the same concentrations.

Original language	English
Pages (from-to)	172-175
Number of pages	4
Journal	Farmacia
Volume	66
Issue number	1
State	Published - 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

A459 cell line
Dry powder inhalation
Meloxicam
Meloxicam potassium

Cite this

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title = "Cytotoxicity of inhalable dry powders in A549 human lung cancer cell line",

abstract = "The aim of the present work was to study the cytotoxicity of meloxicam potassium (MP) containing dry powder inhalation systems (DPIs) in monolayers of A549 lung epithelial cells, in order to acquire information on its suitability for pulmonary drug delivery. We also characterized the effect of the used excipients (such as aerosolization enhancer additives and polymers) on the cytotoxicity of the formulated DPIs. We reported for the first time the cytotoxicity of MP in comparison with meloxicam (M) and the results showed that no difference in the safety can be determined at 0.01 and 0.1 mg/mL concentrations. The protective effect of L-leucine was observed in some formulations, while the use of poly-vinyl-alcohol (PVA) decreases this advantage. Comparing the two polymers it can be established that the poly-vinyl-pirrolidon (PVP) is less toxic than the PVA in the same concentrations.",

keywords = "A459 cell line, Dry powder inhalation, Meloxicam, Meloxicam potassium",

author = "Anita Chvatal and Rami Alzhrani and Tiwari, \{Amit K.\} and Rita Ambrus and Piroska Szab{\'o}-R{\'e}v{\'e}sz and Boddu, \{Sai H.S.\}",

year = "2018",

language = "English",

volume = "66",

pages = "172--175",

journal = "Farmacia",

issn = "0014-8237",

publisher = "Romanian Society for Pharmaceutical Sciences",

number = "1",

}

TY - JOUR

T1 - Cytotoxicity of inhalable dry powders in A549 human lung cancer cell line

AU - Chvatal, Anita

AU - Alzhrani, Rami

AU - Tiwari, Amit K.

AU - Ambrus, Rita

AU - Szabó-Révész, Piroska

AU - Boddu, Sai H.S.

PY - 2018

Y1 - 2018

N2 - The aim of the present work was to study the cytotoxicity of meloxicam potassium (MP) containing dry powder inhalation systems (DPIs) in monolayers of A549 lung epithelial cells, in order to acquire information on its suitability for pulmonary drug delivery. We also characterized the effect of the used excipients (such as aerosolization enhancer additives and polymers) on the cytotoxicity of the formulated DPIs. We reported for the first time the cytotoxicity of MP in comparison with meloxicam (M) and the results showed that no difference in the safety can be determined at 0.01 and 0.1 mg/mL concentrations. The protective effect of L-leucine was observed in some formulations, while the use of poly-vinyl-alcohol (PVA) decreases this advantage. Comparing the two polymers it can be established that the poly-vinyl-pirrolidon (PVP) is less toxic than the PVA in the same concentrations.

AB - The aim of the present work was to study the cytotoxicity of meloxicam potassium (MP) containing dry powder inhalation systems (DPIs) in monolayers of A549 lung epithelial cells, in order to acquire information on its suitability for pulmonary drug delivery. We also characterized the effect of the used excipients (such as aerosolization enhancer additives and polymers) on the cytotoxicity of the formulated DPIs. We reported for the first time the cytotoxicity of MP in comparison with meloxicam (M) and the results showed that no difference in the safety can be determined at 0.01 and 0.1 mg/mL concentrations. The protective effect of L-leucine was observed in some formulations, while the use of poly-vinyl-alcohol (PVA) decreases this advantage. Comparing the two polymers it can be established that the poly-vinyl-pirrolidon (PVP) is less toxic than the PVA in the same concentrations.

KW - A459 cell line

KW - Dry powder inhalation

KW - Meloxicam

KW - Meloxicam potassium

UR - https://www.scopus.com/pages/publications/85042400336

M3 - Article

AN - SCOPUS:85042400336

SN - 0014-8237

VL - 66

SP - 172

EP - 175

JO - Farmacia

JF - Farmacia

IS - 1

ER -

Cytotoxicity of inhalable dry powders in A549 human lung cancer cell line

Abstract

UN SDGs

Keywords

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