Cytotoxic effect and antibacterial activity of coriander oleoresin mediated zinc oxide nanoparticles

Aim: Zinc oxide nanoparticles can be multidimensionally used for treatment, targeting and diagnosis of lung, breast, skin and many other cancer or tumors. Coriander oleoresin is derived from dried seeds of Coriandrum sativum. Common uses of coriander include its application as a diuretic, an antidepressant and a memoryenhancing compound. Also, it has been shown to exhibit great antioxidative capacity due to its polyphenolic compounds and further antidiabetic and antimutagenic effects. The aim of the present study was to evaluate the antibacterial activity and cytotoxic activity of coriander oleoresin mediated ZnO nanoparticles. Materials and methods: In the present investigation, coriander oleoresin mediated synthesis of ZnO nanoparticles was carried out initially and then confirmed by UV-Visible spectroscopy. The antibacterial activity of the synthesis ZnO nanoparticles was carried out using agar well diffusion method. Different concentrations of zinc nanoparticles were tested against Streptococcus mutans, lactobacillus and Candida albicans. Results: The zinc nanoparticles prepared from coriander oleoresin showed good anti-inflammatory activity. The zinc nanoparticles were analysed using UV- Visible spectroscopy and were found to be at an absorbance range of 300 to 700nm. The peak was found to be a maximum of 350 nm. The synthesised nanoparticles showed maximum anti-bacterial activity with 9 mm at 150 μL concentration. The study did not exhibit any cytotoxic activity. Conclusion: In the present study, it was observed that coriander oleoresin mediated zinc nanoparticles had antibacterial property and also did not exhibit any cytotoxic activity. Green synthesis of Zinc nanoparticles using coriander oleoresin was of low cost and was convenient to carry out. Hence, coriander oleoresin mediated zinc nanoparticles may be used for the control of oral pathogens in large scales.