CYD-TDV dengue vaccine: Systematic review and meta-analysis of efficacy, immunogenicity and safety

Isabella Piassi Godói; Livia Lovato Pires Lemos; Vânia Eloisa De Araújo; Braúlio Cesar Bonoto; Brian Godman; Augusto Afonso Guerra Júnior

doi:10.2217/cer-2016-0045

CYD-TDV dengue vaccine: Systematic review and meta-analysis of efficacy, immunogenicity and safety

Isabella Piassi Godói
, Livia Lovato Pires Lemos
, Vânia Eloisa De Araújo
, Braúlio Cesar Bonoto
, Brian Godman
, Augusto Afonso Guerra Júnior

Universidade Federal de Minas Gerais
Pontifícia Universidade Católica de Minas Gerais
University of Strathclyde
Karolinska Institutet

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Introduction: Dengue virus (DENV) is a serious global health problem. CYD-TDC (Dengvaxia^®) was the first vaccine to gain regulatory approval to try and address this problem. Aim: Summarize all available evidence on the immunogenicity, efficacy and safety of the CYD-TDV dengue vaccine. Method: Meta-analysis and systematic review. Results: The best and worst immunogenicity results were for DENV4 and DENV1, respectively. Vaccine efficacy of 60% was derived from studies with participants aged 2-16 years old, with DENV4 and DENV2 presenting the best and worst results, respectively. Erythema and swelling were more frequent with CYD-TDV. No differences were detected for systemic adverse events. Conclusion: CYD-TDV showed moderate efficacy in children and adolescents. From the immunogenicity results in adults, we can expect satisfactory efficacy from vaccination in this population.

Original language	English
Pages (from-to)	165-180
Number of pages	16
Journal	Journal of Comparative Effectiveness Research
Volume	6
Issue number	2
DOIs	https://doi.org/10.2217/cer-2016-0045
State	Published - Mar 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CYD-TDV
dengue
meta-analysis
systematic review
vaccines

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10.2217/cer-2016-0045

Cite this

@article{7f831495d2fe46c7bc39a59555c9d26e,

title = "CYD-TDV dengue vaccine: Systematic review and meta-analysis of efficacy, immunogenicity and safety",

abstract = "Introduction: Dengue virus (DENV) is a serious global health problem. CYD-TDC (Dengvaxia{\textregistered}) was the first vaccine to gain regulatory approval to try and address this problem. Aim: Summarize all available evidence on the immunogenicity, efficacy and safety of the CYD-TDV dengue vaccine. Method: Meta-analysis and systematic review. Results: The best and worst immunogenicity results were for DENV4 and DENV1, respectively. Vaccine efficacy of 60\% was derived from studies with participants aged 2-16 years old, with DENV4 and DENV2 presenting the best and worst results, respectively. Erythema and swelling were more frequent with CYD-TDV. No differences were detected for systemic adverse events. Conclusion: CYD-TDV showed moderate efficacy in children and adolescents. From the immunogenicity results in adults, we can expect satisfactory efficacy from vaccination in this population.",

keywords = "CYD-TDV, dengue, meta-analysis, systematic review, vaccines",

author = "God{\'o}i, \{Isabella Piassi\} and Lemos, \{Livia Lovato Pires\} and \{De Ara{\'u}jo\}, \{V{\^a}nia Eloisa\} and Bonoto, \{Bra{\'u}lio Cesar\} and Brian Godman and \{Guerra J{\'u}nior\}, \{Augusto Afonso\}",

note = "Publisher Copyright: {\textcopyright} 2017 Future Medicine Ltd.",

year = "2017",

month = mar,

doi = "10.2217/cer-2016-0045",

language = "English",

volume = "6",

pages = "165--180",

journal = "Journal of Comparative Effectiveness Research",

issn = "2042-6305",

publisher = "Becaris Publishing Ltd",

number = "2",

}

TY - JOUR

T1 - CYD-TDV dengue vaccine

T2 - Systematic review and meta-analysis of efficacy, immunogenicity and safety

AU - Godói, Isabella Piassi

AU - Lemos, Livia Lovato Pires

AU - De Araújo, Vânia Eloisa

AU - Bonoto, Braúlio Cesar

AU - Godman, Brian

AU - Guerra Júnior, Augusto Afonso

PY - 2017/3

Y1 - 2017/3

N2 - Introduction: Dengue virus (DENV) is a serious global health problem. CYD-TDC (Dengvaxia®) was the first vaccine to gain regulatory approval to try and address this problem. Aim: Summarize all available evidence on the immunogenicity, efficacy and safety of the CYD-TDV dengue vaccine. Method: Meta-analysis and systematic review. Results: The best and worst immunogenicity results were for DENV4 and DENV1, respectively. Vaccine efficacy of 60% was derived from studies with participants aged 2-16 years old, with DENV4 and DENV2 presenting the best and worst results, respectively. Erythema and swelling were more frequent with CYD-TDV. No differences were detected for systemic adverse events. Conclusion: CYD-TDV showed moderate efficacy in children and adolescents. From the immunogenicity results in adults, we can expect satisfactory efficacy from vaccination in this population.

AB - Introduction: Dengue virus (DENV) is a serious global health problem. CYD-TDC (Dengvaxia®) was the first vaccine to gain regulatory approval to try and address this problem. Aim: Summarize all available evidence on the immunogenicity, efficacy and safety of the CYD-TDV dengue vaccine. Method: Meta-analysis and systematic review. Results: The best and worst immunogenicity results were for DENV4 and DENV1, respectively. Vaccine efficacy of 60% was derived from studies with participants aged 2-16 years old, with DENV4 and DENV2 presenting the best and worst results, respectively. Erythema and swelling were more frequent with CYD-TDV. No differences were detected for systemic adverse events. Conclusion: CYD-TDV showed moderate efficacy in children and adolescents. From the immunogenicity results in adults, we can expect satisfactory efficacy from vaccination in this population.

KW - CYD-TDV

KW - dengue

KW - meta-analysis

KW - systematic review

KW - vaccines

UR - https://www.scopus.com/pages/publications/85011629651

U2 - 10.2217/cer-2016-0045

DO - 10.2217/cer-2016-0045

M3 - Review article

C2 - 28084784

AN - SCOPUS:85011629651

SN - 2042-6305

VL - 6

SP - 165

EP - 180

JO - Journal of Comparative Effectiveness Research

JF - Journal of Comparative Effectiveness Research

IS - 2

ER -

CYD-TDV dengue vaccine: Systematic review and meta-analysis of efficacy, immunogenicity and safety

Abstract

UN SDGs

Keywords

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