Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

Daljeet Singh Dhanjal; Parvarish Sharma; Meenu Mehta; Murtaza M. Tambuwala; Parteek Prasher; Keshav R. Paudel; Gang Liu; Shakti D. Shukla; Philip M. Hansbro; Dinesh Kumar Chellappan; Kamal Dua; Saurabh Satija

doi:10.4155/fmc-2021-0081

Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

Daljeet Singh Dhanjal
, Parvarish Sharma
, Meenu Mehta
, Murtaza M. Tambuwala
, Parteek Prasher
, Keshav R. Paudel
, Gang Liu
, Shakti D. Shukla
, Philip M. Hansbro
, Dinesh Kumar Chellappan
, Kamal Dua
, Saurabh Satija

Lovely Professional University
University of Technology Sydney
Ulster University
University of Petroleum and Energy Studies
International Medical University

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Chronic respiratory disorders affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.

Original language	English
Pages (from-to)	271-288
Number of pages	18
Journal	Future Medicinal Chemistry
Volume	14
Issue number	4
DOIs	https://doi.org/10.4155/fmc-2021-0081
State	Published - Feb 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COPD
NDDS
remodeling
respiratory disorders

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10.4155/fmc-2021-0081

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Dhanjal, D. S., Sharma, P., Mehta, M., Tambuwala, M. M., Prasher, P., Paudel, K. R., Liu, G., Shukla, S. D., Hansbro, P. M., Chellappan, D. K., Dua, K., & Satija, S. (2022). Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases. Future Medicinal Chemistry, 14(4), 271-288. https://doi.org/10.4155/fmc-2021-0081

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title = "Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases",

abstract = "Chronic respiratory disorders affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.",

keywords = "COPD, NDDS, remodeling, respiratory disorders",

author = "Dhanjal, \{Daljeet Singh\} and Parvarish Sharma and Meenu Mehta and Tambuwala, \{Murtaza M.\} and Parteek Prasher and Paudel, \{Keshav R.\} and Gang Liu and Shukla, \{Shakti D.\} and Hansbro, \{Philip M.\} and Chellappan, \{Dinesh Kumar\} and Kamal Dua and Saurabh Satija",

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doi = "10.4155/fmc-2021-0081",

language = "English",

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AU - Dhanjal, Daljeet Singh

AU - Sharma, Parvarish

AU - Mehta, Meenu

AU - Tambuwala, Murtaza M.

AU - Prasher, Parteek

AU - Paudel, Keshav R.

AU - Liu, Gang

AU - Shukla, Shakti D.

AU - Hansbro, Philip M.

AU - Chellappan, Dinesh Kumar

AU - Dua, Kamal

AU - Satija, Saurabh

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N2 - Chronic respiratory disorders affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.

AB - Chronic respiratory disorders affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.

KW - COPD

KW - NDDS

KW - remodeling

KW - respiratory disorders

UR - https://www.scopus.com/pages/publications/85124173631

U2 - 10.4155/fmc-2021-0081

DO - 10.4155/fmc-2021-0081

M3 - Review article

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AN - SCOPUS:85124173631

SN - 1756-8919

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EP - 288

JO - Future Medicinal Chemistry

JF - Future Medicinal Chemistry

IS - 4

ER -

Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

Abstract

UN SDGs

Keywords

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