Collagen/physiologically clotted fibrin-based nanobioscaffold supported with silver nanoparticles: A novel approach

Rethinam Senthil; Serdar Batıkan Kavukcu; Thangavelu Lakshmi; Türkmen Gülşah; Adıgüzel Zengin Arife Candaş

doi:10.1177/03913988221119529

Collagen/physiologically clotted fibrin-based nanobioscaffold supported with silver nanoparticles: A novel approach

Rethinam Senthil
, Serdar Batıkan Kavukcu
, Thangavelu Lakshmi
, Türkmen Gülşah
, Adıgüzel Zengin Arife Candaş

Ege University
Sathyabama University
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Purpose: In this work, a blend of collagen, physiologically clotted fibrin (PCF), and silver nanoparticles (AgNPs) is used to develop a nanobioscaffold (NBS), for their possible application in wound dressing materials. Methods: The prepared NBS were evaluated using physicochemical, mechanical, and antibacterial properties. The NBS cell viability was demonstrated in a biocompatibility study using the human keratinocyte cell line (HaCaT). Results: The results demonstrated that the NBS had excellent tensile strength (22.15 ± 0.05 MPa), elongation at break (13.32 ± 0.09%), and water absorption (97.51 ± 0.08). The in-vitro study demonstrated its biocompatible nature. NBS exhibited significant antibacterial activity against the Gram-negative and Gram-positive bacteria. Conclusion: The NBS with required mechanical strength, antibacterial activity, and biocompatibility may be tested as a wound material in rats after getting the necessary approval.

Original language	English
Pages (from-to)	1021-1027
Number of pages	7
Journal	International Journal of Artificial Organs
Volume	45
Issue number	12
DOIs	https://doi.org/10.1177/03913988221119529
State	Published - Dec 2022
Externally published	Yes

Keywords

Nanobioscaffolds
antibacterial
biocompatibility
collagen
fibrin

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10.1177/03913988221119529

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title = "Collagen/physiologically clotted fibrin-based nanobioscaffold supported with silver nanoparticles: A novel approach",

abstract = "Purpose: In this work, a blend of collagen, physiologically clotted fibrin (PCF), and silver nanoparticles (AgNPs) is used to develop a nanobioscaffold (NBS), for their possible application in wound dressing materials. Methods: The prepared NBS were evaluated using physicochemical, mechanical, and antibacterial properties. The NBS cell viability was demonstrated in a biocompatibility study using the human keratinocyte cell line (HaCaT). Results: The results demonstrated that the NBS had excellent tensile strength (22.15 ± 0.05 MPa), elongation at break (13.32 ± 0.09\%), and water absorption (97.51 ± 0.08). The in-vitro study demonstrated its biocompatible nature. NBS exhibited significant antibacterial activity against the Gram-negative and Gram-positive bacteria. Conclusion: The NBS with required mechanical strength, antibacterial activity, and biocompatibility may be tested as a wound material in rats after getting the necessary approval.",

keywords = "Nanobioscaffolds, antibacterial, biocompatibility, collagen, fibrin",

author = "Rethinam Senthil and Kavukcu, \{Serdar Batıkan\} and Thangavelu Lakshmi and T{\"u}rkmen G{\"u}l{\c s}ah and \{Arife Canda{\c s}\}, \{Adıg{\"u}zel Zengin\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2022.",

year = "2022",

month = dec,

doi = "10.1177/03913988221119529",

language = "English",

volume = "45",

pages = "1021--1027",

journal = "International Journal of Artificial Organs",

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}

TY - JOUR

T1 - Collagen/physiologically clotted fibrin-based nanobioscaffold supported with silver nanoparticles

T2 - A novel approach

AU - Senthil, Rethinam

AU - Kavukcu, Serdar Batıkan

AU - Lakshmi, Thangavelu

AU - Gülşah, Türkmen

AU - Arife Candaş, Adıgüzel Zengin

N1 - Publisher Copyright: © The Author(s) 2022.

PY - 2022/12

Y1 - 2022/12

N2 - Purpose: In this work, a blend of collagen, physiologically clotted fibrin (PCF), and silver nanoparticles (AgNPs) is used to develop a nanobioscaffold (NBS), for their possible application in wound dressing materials. Methods: The prepared NBS were evaluated using physicochemical, mechanical, and antibacterial properties. The NBS cell viability was demonstrated in a biocompatibility study using the human keratinocyte cell line (HaCaT). Results: The results demonstrated that the NBS had excellent tensile strength (22.15 ± 0.05 MPa), elongation at break (13.32 ± 0.09%), and water absorption (97.51 ± 0.08). The in-vitro study demonstrated its biocompatible nature. NBS exhibited significant antibacterial activity against the Gram-negative and Gram-positive bacteria. Conclusion: The NBS with required mechanical strength, antibacterial activity, and biocompatibility may be tested as a wound material in rats after getting the necessary approval.

AB - Purpose: In this work, a blend of collagen, physiologically clotted fibrin (PCF), and silver nanoparticles (AgNPs) is used to develop a nanobioscaffold (NBS), for their possible application in wound dressing materials. Methods: The prepared NBS were evaluated using physicochemical, mechanical, and antibacterial properties. The NBS cell viability was demonstrated in a biocompatibility study using the human keratinocyte cell line (HaCaT). Results: The results demonstrated that the NBS had excellent tensile strength (22.15 ± 0.05 MPa), elongation at break (13.32 ± 0.09%), and water absorption (97.51 ± 0.08). The in-vitro study demonstrated its biocompatible nature. NBS exhibited significant antibacterial activity against the Gram-negative and Gram-positive bacteria. Conclusion: The NBS with required mechanical strength, antibacterial activity, and biocompatibility may be tested as a wound material in rats after getting the necessary approval.

KW - Nanobioscaffolds

KW - antibacterial

KW - biocompatibility

KW - collagen

KW - fibrin

UR - https://www.scopus.com/pages/publications/85136585841

U2 - 10.1177/03913988221119529

DO - 10.1177/03913988221119529

M3 - Article

C2 - 35993241

AN - SCOPUS:85136585841

SN - 0391-3988

VL - 45

SP - 1021

EP - 1027

JO - International Journal of Artificial Organs

JF - International Journal of Artificial Organs

IS - 12

ER -

Collagen/physiologically clotted fibrin-based nanobioscaffold supported with silver nanoparticles: A novel approach

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Keywords

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