Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues

Xingzhi Wang; Nitesh Tewari; Fuyuki Sato; Keiji Tanimoto; Lakshmi Thangavelu; Makoto Makishima; Ujjal K. Bhawal

doi:10.3390/ijms23020962

Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues

Xingzhi Wang
, Nitesh Tewari
, Fuyuki Sato
, Keiji Tanimoto
, Lakshmi Thangavelu
, Makoto Makishima
, Ujjal K. Bhawal

Nihon University
All India Institute of Medical Sciences, New Delhi
Shizuoka Cancer Center
Hiroshima University
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Sodium fluoride (NaF) is widely used in clinical dentistry. However, the administration of high or low concentrations of NaF has various functions in different tissues. Understanding the mechanisms of the different effects of NaF will help to optimize its use in clinical applications. Studies of NaF and epithelial cells, osteoblasts, osteoclasts, and periodontal cells have suggested the significant roles of fluoride treatment. In this review, we summarize recent studies on the biphasic functions of NaF that are related to both soft and hard periodontal tissues, multiple diseases, and clinical dentistry.

Original language	English
Article number	962
Journal	International Journal of Molecular Sciences
Volume	23
Issue number	2
DOIs	https://doi.org/10.3390/ijms23020962
State	Published - 1 Jan 2022
Externally published	Yes

Keywords

Epithelial cells
Fluoride
Mesenchymal stem cells
MiRNA
Osteoblasts
Osteoclasts
Periodontal disease

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10.3390/ijms23020962

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title = "Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues",

abstract = "Sodium fluoride (NaF) is widely used in clinical dentistry. However, the administration of high or low concentrations of NaF has various functions in different tissues. Understanding the mechanisms of the different effects of NaF will help to optimize its use in clinical applications. Studies of NaF and epithelial cells, osteoblasts, osteoclasts, and periodontal cells have suggested the significant roles of fluoride treatment. In this review, we summarize recent studies on the biphasic functions of NaF that are related to both soft and hard periodontal tissues, multiple diseases, and clinical dentistry.",

keywords = "Epithelial cells, Fluoride, Mesenchymal stem cells, MiRNA, Osteoblasts, Osteoclasts, Periodontal disease",

author = "Xingzhi Wang and Nitesh Tewari and Fuyuki Sato and Keiji Tanimoto and Lakshmi Thangavelu and Makoto Makishima and Bhawal, \{Ujjal K.\}",

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T1 - Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues

AU - Wang, Xingzhi

AU - Tewari, Nitesh

AU - Sato, Fuyuki

AU - Tanimoto, Keiji

AU - Thangavelu, Lakshmi

AU - Makishima, Makoto

AU - Bhawal, Ujjal K.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Sodium fluoride (NaF) is widely used in clinical dentistry. However, the administration of high or low concentrations of NaF has various functions in different tissues. Understanding the mechanisms of the different effects of NaF will help to optimize its use in clinical applications. Studies of NaF and epithelial cells, osteoblasts, osteoclasts, and periodontal cells have suggested the significant roles of fluoride treatment. In this review, we summarize recent studies on the biphasic functions of NaF that are related to both soft and hard periodontal tissues, multiple diseases, and clinical dentistry.

AB - Sodium fluoride (NaF) is widely used in clinical dentistry. However, the administration of high or low concentrations of NaF has various functions in different tissues. Understanding the mechanisms of the different effects of NaF will help to optimize its use in clinical applications. Studies of NaF and epithelial cells, osteoblasts, osteoclasts, and periodontal cells have suggested the significant roles of fluoride treatment. In this review, we summarize recent studies on the biphasic functions of NaF that are related to both soft and hard periodontal tissues, multiple diseases, and clinical dentistry.

KW - Epithelial cells

KW - Fluoride

KW - Mesenchymal stem cells

KW - MiRNA

KW - Osteoblasts

KW - Osteoclasts

KW - Periodontal disease

UR - https://www.scopus.com/pages/publications/85122780420

U2 - 10.3390/ijms23020962

DO - 10.3390/ijms23020962

M3 - Review article

C2 - 35055148

AN - SCOPUS:85122780420

SN - 1661-6596

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 2

M1 - 962

ER -

Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues

Abstract

Keywords

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