Bacteria-Induced Carcinopathogenesis in Oral Squamous Cell Carcinoma

Swagatika Panda; Divya Gopinath; Newell W. Johnson

doi:10.1007/978-981-19-0592-6_9

Bacteria-Induced Carcinopathogenesis in Oral Squamous Cell Carcinoma

Swagatika Panda
, Divya Gopinath
, Newell W. Johnson

Siksha ‘O’ Anusandhan University
International Medical University
Griffith University Queensland
King's College London

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

The human oral microbiome plays an important role in host physiology. The causes and factors that influence the microbiota are closely linked to the cause of a disease. Some oral taxa, especially Porphyromonas gingivalis and Fusobacterium nucleatum, induce carcinogenesis by several different mechanisms, like inhibiting apoptosis, inducing cell proliferation, cellular invasion, migration and chronic inflammation. These changes are seen parallel with the malignant lesions developed in the oral cavity. Starting with a brief introduction on eubiosis and dysbiosis of oral microbiome this chapter has highlighted the role of structural and metabolic attributes of bacteria in oral carcinogenesis via influencing the eight established hallmarks of cancer.

Original language	English
Title of host publication	Microbes and Oral Squamous Cell Carcinoma
Subtitle of host publication	A Network Spanning Infection and Inflammation
Publisher	Springer Nature
Pages	107-124
Number of pages	18
ISBN (Electronic)	9789811905926
ISBN (Print)	9789811905919
DOIs	https://doi.org/10.1007/978-981-19-0592-6_9
State	Published - 1 Jan 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bacteria
Carcinopathogenesis
OSCC

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10.1007/978-981-19-0592-6_9

Cite this

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title = "Bacteria-Induced Carcinopathogenesis in Oral Squamous Cell Carcinoma",

abstract = "The human oral microbiome plays an important role in host physiology. The causes and factors that influence the microbiota are closely linked to the cause of a disease. Some oral taxa, especially Porphyromonas gingivalis and Fusobacterium nucleatum, induce carcinogenesis by several different mechanisms, like inhibiting apoptosis, inducing cell proliferation, cellular invasion, migration and chronic inflammation. These changes are seen parallel with the malignant lesions developed in the oral cavity. Starting with a brief introduction on eubiosis and dysbiosis of oral microbiome this chapter has highlighted the role of structural and metabolic attributes of bacteria in oral carcinogenesis via influencing the eight established hallmarks of cancer.",

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AU - Panda, Swagatika

AU - Gopinath, Divya

AU - Johnson, Newell W.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - The human oral microbiome plays an important role in host physiology. The causes and factors that influence the microbiota are closely linked to the cause of a disease. Some oral taxa, especially Porphyromonas gingivalis and Fusobacterium nucleatum, induce carcinogenesis by several different mechanisms, like inhibiting apoptosis, inducing cell proliferation, cellular invasion, migration and chronic inflammation. These changes are seen parallel with the malignant lesions developed in the oral cavity. Starting with a brief introduction on eubiosis and dysbiosis of oral microbiome this chapter has highlighted the role of structural and metabolic attributes of bacteria in oral carcinogenesis via influencing the eight established hallmarks of cancer.

AB - The human oral microbiome plays an important role in host physiology. The causes and factors that influence the microbiota are closely linked to the cause of a disease. Some oral taxa, especially Porphyromonas gingivalis and Fusobacterium nucleatum, induce carcinogenesis by several different mechanisms, like inhibiting apoptosis, inducing cell proliferation, cellular invasion, migration and chronic inflammation. These changes are seen parallel with the malignant lesions developed in the oral cavity. Starting with a brief introduction on eubiosis and dysbiosis of oral microbiome this chapter has highlighted the role of structural and metabolic attributes of bacteria in oral carcinogenesis via influencing the eight established hallmarks of cancer.

KW - Bacteria

KW - Carcinopathogenesis

KW - OSCC

UR - https://www.scopus.com/pages/publications/85173393274

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DO - 10.1007/978-981-19-0592-6_9

M3 - Chapter

AN - SCOPUS:85173393274

SN - 9789811905919

SP - 107

EP - 124

BT - Microbes and Oral Squamous Cell Carcinoma

PB - Springer Nature

ER -

Bacteria-Induced Carcinopathogenesis in Oral Squamous Cell Carcinoma

Abstract

UN SDGs

Keywords

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