Association between abnormal serum hepatic enzymes, lipid levels and glycemic control in patients with type 2 diabetes mellitus

Aims: To assess the association between abnormal hepatic enzyme, lipid levels and glycemic control in patients with type 2 Diabetes Mellitus. As Liver biomarkers serve as an effective indicator of liver injury in patients whom liver functions are somewhat above average. The abnormality of these markers acts as an alarming sign to the liver function. Since type 2 diabetes can negatively affect the liver via insulin resistance, these biomarkers maybe linked with the severity of the disease. Materials and methods: A cross-sectional study was carried out at private health care center. A total of 453 diabetic patients. Socio-demographic, clinical, and laboratory data were obtained from the medical records of patients. Statistical analysis was carried out using the Statistical Package for the Social Sciences (SPSS, version 23). Results: A total number of 453 patients with T2DM were included in this study. Of the 453 patients, 366 (80.8%) had only one abnormal hepatic profile parameter (ALT, AST & Albumin), 29 (6.4%) had two abnormal hepatic parameters and 11 (2.4%) had more than two abnormal hepatic profile parameters. The results of statistical modeling showed that mean Albumin, mean ALT, and mean AST are jointly highly associated with poorly controlled diabetes mellitus (HbA1c ≥ 7). Lipid profiles (TC, LDL-C and TG) were significantly associated with abnormal hepatic findings. Conclusion: Current study revealed significant association in liver biomarkers among type 2 diabetic patients.