Applications of nanocarriers as drug delivery vehicles for active phytoconstituents

Phui Qi Ng; Laura Soon Cheau Ling; Jestin Chellian; Thiagarajan Madheswaran; Jithendra Panneersel-Vam; Anil Philip Kunnath; Gaurav Gupta; Saurabh Satija; Meenu Mehta; Philip Michael Hansbro; Trudi Collet; Kamal Dua; Dinesh Kumar Chellappan

doi:10.2174/1381612826666200610111013

Applications of nanocarriers as drug delivery vehicles for active phytoconstituents

Phui Qi Ng
, Laura Soon Cheau Ling
, Jestin Chellian
, Thiagarajan Madheswaran
, Jithendra Panneersel-Vam
, Anil Philip Kunnath
, Gaurav Gupta
, Saurabh Satija
, Meenu Mehta
, Philip Michael Hansbro
, Trudi Collet
, Kamal Dua
, Dinesh Kumar Chellappan

International Medical University
Suresh Gyan Vihar University
Lovely Professional University
University of Technology Sydney
Royal Prince Alfred Hospital
University of Newcastle
Queensland University of Technology

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Many plant-based bioactive compounds have been serving as the origin of drugs since long ago and many of them have been proven to have medicinal value against various chronic diseases, including, cancer, arthritis, hepatic diseases, type-2 diabetes and cardiovascular diseases. However, their clinical applications have been limited due to their poor water solubility, stability, low bioavailability and extensive transformation due to the first-pass metabolism. The applications of nanocarriers have been proven to be able to improve the delivery of bioactive phytoconstituents, resulting in the enhancement of various pharmacokinetic properties and thereby increasing the therapeutic value of phytoconstituents. These biocompatible nanocarriers also exert low toxicity to healthy cells. This review focuses on the uses and applications of different types of nanocarriers to enhance the delivery of phytoconstituents for the treatment of various chronic diseases, along with comparisons related to bioavailability and therapeutic efficacy of nano phytoconstituents with native phytoconstituents. delivery bioavailability.

Original language	English
Pages (from-to)	4580-4590
Number of pages	11
Journal	Current Pharmaceutical Design
Volume	26
Issue number	36
DOIs	https://doi.org/10.2174/1381612826666200610111013
State	Published - 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bioavailability
Chronic diseases
Nanocarriers
Nanomedicine
Nanoparticles
Phytoconstituents

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10.2174/1381612826666200610111013

Cite this

Ng, P. Q., Ling, L. S. C., Chellian, J., Madheswaran, T., Panneersel-Vam, J., Kunnath, A. P., Gupta, G., Satija, S., Mehta, M., Hansbro, P. M., Collet, T., Dua, K., & Chellappan, D. K. (2020). Applications of nanocarriers as drug delivery vehicles for active phytoconstituents. Current Pharmaceutical Design, 26(36), 4580-4590. https://doi.org/10.2174/1381612826666200610111013

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title = "Applications of nanocarriers as drug delivery vehicles for active phytoconstituents",

abstract = "Many plant-based bioactive compounds have been serving as the origin of drugs since long ago and many of them have been proven to have medicinal value against various chronic diseases, including, cancer, arthritis, hepatic diseases, type-2 diabetes and cardiovascular diseases. However, their clinical applications have been limited due to their poor water solubility, stability, low bioavailability and extensive transformation due to the first-pass metabolism. The applications of nanocarriers have been proven to be able to improve the delivery of bioactive phytoconstituents, resulting in the enhancement of various pharmacokinetic properties and thereby increasing the therapeutic value of phytoconstituents. These biocompatible nanocarriers also exert low toxicity to healthy cells. This review focuses on the uses and applications of different types of nanocarriers to enhance the delivery of phytoconstituents for the treatment of various chronic diseases, along with comparisons related to bioavailability and therapeutic efficacy of nano phytoconstituents with native phytoconstituents. delivery bioavailability.",

keywords = "Bioavailability, Chronic diseases, Nanocarriers, Nanomedicine, Nanoparticles, Phytoconstituents",

author = "Ng, \{Phui Qi\} and Ling, \{Laura Soon Cheau\} and Jestin Chellian and Thiagarajan Madheswaran and Jithendra Panneersel-Vam and Kunnath, \{Anil Philip\} and Gaurav Gupta and Saurabh Satija and Meenu Mehta and Hansbro, \{Philip Michael\} and Trudi Collet and Kamal Dua and Chellappan, \{Dinesh Kumar\}",

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year = "2020",

doi = "10.2174/1381612826666200610111013",

language = "English",

volume = "26",

pages = "4580--4590",

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TY - JOUR

T1 - Applications of nanocarriers as drug delivery vehicles for active phytoconstituents

AU - Ng, Phui Qi

AU - Ling, Laura Soon Cheau

AU - Chellian, Jestin

AU - Madheswaran, Thiagarajan

AU - Panneersel-Vam, Jithendra

AU - Kunnath, Anil Philip

AU - Gupta, Gaurav

AU - Satija, Saurabh

AU - Mehta, Meenu

AU - Hansbro, Philip Michael

AU - Collet, Trudi

AU - Dua, Kamal

AU - Chellappan, Dinesh Kumar

PY - 2020

Y1 - 2020

N2 - Many plant-based bioactive compounds have been serving as the origin of drugs since long ago and many of them have been proven to have medicinal value against various chronic diseases, including, cancer, arthritis, hepatic diseases, type-2 diabetes and cardiovascular diseases. However, their clinical applications have been limited due to their poor water solubility, stability, low bioavailability and extensive transformation due to the first-pass metabolism. The applications of nanocarriers have been proven to be able to improve the delivery of bioactive phytoconstituents, resulting in the enhancement of various pharmacokinetic properties and thereby increasing the therapeutic value of phytoconstituents. These biocompatible nanocarriers also exert low toxicity to healthy cells. This review focuses on the uses and applications of different types of nanocarriers to enhance the delivery of phytoconstituents for the treatment of various chronic diseases, along with comparisons related to bioavailability and therapeutic efficacy of nano phytoconstituents with native phytoconstituents. delivery bioavailability.

AB - Many plant-based bioactive compounds have been serving as the origin of drugs since long ago and many of them have been proven to have medicinal value against various chronic diseases, including, cancer, arthritis, hepatic diseases, type-2 diabetes and cardiovascular diseases. However, their clinical applications have been limited due to their poor water solubility, stability, low bioavailability and extensive transformation due to the first-pass metabolism. The applications of nanocarriers have been proven to be able to improve the delivery of bioactive phytoconstituents, resulting in the enhancement of various pharmacokinetic properties and thereby increasing the therapeutic value of phytoconstituents. These biocompatible nanocarriers also exert low toxicity to healthy cells. This review focuses on the uses and applications of different types of nanocarriers to enhance the delivery of phytoconstituents for the treatment of various chronic diseases, along with comparisons related to bioavailability and therapeutic efficacy of nano phytoconstituents with native phytoconstituents. delivery bioavailability.

KW - Bioavailability

KW - Chronic diseases

KW - Nanocarriers

KW - Nanomedicine

KW - Nanoparticles

KW - Phytoconstituents

UR - https://www.scopus.com/pages/publications/85089267900

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DO - 10.2174/1381612826666200610111013

M3 - Review article

C2 - 32520681

AN - SCOPUS:85089267900

SN - 1381-6128

VL - 26

SP - 4580

EP - 4590

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

IS - 36

ER -

Applications of nanocarriers as drug delivery vehicles for active phytoconstituents

Abstract

UN SDGs

Keywords

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