Antidiabetic Activity and Cytotoxic Effect of Selenium Nanoparticles Mediated Through Mimosa Pudica Leaves Extract

The antidiabetic and Cytotoxic effects of Se NPs synthesized by using Mimosa pudica (M.pudica) were examined in this study. The study aims to green synthesis of M. pudica-mediated Selenium Nanoparticles(Se NPs) and elucidate the antidiabetic activity of the synthesized M. pudica-mediated Se NPs. Selenium exhibits significant antidiabetic properties through its antioxidant, anti-inflammatory, and insulin-sensitizing effect The study evaluates brine shrimp lethality assay, alpha-amylase and beta-glucosidase of M. pudica-Se NPs. Both assays verified that M. pudica-mediated Se NPs effectively inhibited the activity of α-amylase and β-glucosidase in a dose-dependent manner. The Se NPs showed substantial inhibitory effects, although slightly lower than the standard antidiabetic drug. low cytotoxic effect on Brine Shrimp Lethality Assay (BSLA), with high survival rates maintained even at elevated concentrations. The slight decrease in survival rates on the second day at higher concentrations suggests a dose-dependent response, but overall, the Se NPs were well-tolerated by the nauplii within the tested concentration range.