Advanced Drug Delivery Approaches Containing Synbiotics

Synbiotics have shown various beneficial effects in inflammatory bowel diseases, irritable bowel syndrome, infectious disorders, and diarrheal illnesses. However, the delivery of probiotics to the host intestine is challenging owing to the poor survivability and viability of probiotic bacteria during the gastric transit, and poor stability at the highly acidic pH of the stomach. The oral delivery of probiotics in combination with prebiotics can achieve the targeted delivery of probiotics toward the intestine. The deliveries of synbiotics through suitable particulate carriers can also be useful to improve the encapsulation efficiency, viability, stability, and performance of probiotics. In addition, these particulate carriers also help to control the release of probiotics at the target site (intestine). This chapter discusses the synbiotics and various particulate carriers in synbiotics delivery along with multiple case studies. Further, the synbiotics in clinical trials and regulatory aspects of synbiotics are also highlighted.