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A review on advancements in the application of starch-based nanomaterials in biomedicine: Precision drug delivery and cancer therapy

  • Jin Jin Pei
  • , Yuqiang Yan
  • , Selvaraj Jayaraman
  • , Ponnulakshmi Rajagopal
  • , Prabhu Manickam Natarajan
  • , Vidhya Rekha Umapathy
  • , Sridevi Gopathy
  • , Jeane Rebecca Roy
  • , Janaki Coimbatore Sadagopan
  • , Dwarakesh Thalamati
  • , Chella Perumal Palanisamy
  • , Monica Mironescu
  • Shaanxi University of Technology
  • Xi'an Central Hospital
  • Saveetha Institute of Medical and Technical Sciences (Deemed to be University)
  • Meenakshi Academy of Higher Education and Research
  • Dr. M.G.R Educational and Research Institute
  • SRM Institute of Science and Technology
  • Bharath Institute of Higher Education and Research
  • Hull University Teaching Hospitals NHS Trust
  • Chulalongkorn University
  • Lucian Blaga University of Sibiu

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

The burgeoning field of starch-based nanomaterials in biomedical applications has perceived notable progressions, with a particular emphasis on their pivotal role in precision drug delivery and the inhibition of tumor growth. The complicated challenges in current biomedical research require innovative approaches for improved therapeutic outcomes, prompting an exploration into the possible of starch-based nanomaterials. The conceptualization of this review emerged from recognizing the need for a comprehensive examination of the structural attributes, versatile properties, and mechanisms underlying the efficiency of starch-based nanomaterials in inhibiting tumor growth and enabling targeted drug delivery. This review delineates the substantial growth in utilizing starch-based nanomaterials, elucidating their small size, high surface-volume ratio, and biocompatibility, predominantly emphasizing their possible to actively recognize cancer cells, deliver anticancer drugs, and combat tumors efficiently. The investigation of these nanomaterials encompasses to improving biocompatibility and targeting specific tissues, thereby contributing to the evolving landscape of precision medicine. The review accomplishes by highlighting the auspicious strategies and modern developments in the field, envisioning a future where starch-based nanomaterials play a transformative role in molecular nanomaterials, evolving biomedical sciences. The translation of these advancements into clinical applications holds the potential to revolutionize targeted drug delivery and expand therapeutic outcomes in the realm of precision medicine.

Original languageEnglish
Article number130746
JournalInternational Journal of Biological Macromolecules
Volume265
DOIs
StatePublished - Apr 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Antitumor mechanisms
  • Starch-based nanomaterials
  • Structural characterizations
  • Versatile properties

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