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A Computational Study and Stability Analysis of a Mathematical Model for In Vitro Inhibition of Cancer Cell Mutation

  • University of Dayton
  • Gulf University for Science and Technology

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Human homeostasis is the body’s ability to physiologically regulate its inner environment to ensure its stability in response to changes in the outside environment. An inability to maintain homeostasis may lead to death or disease, which is caused by a condition known as homeostatic imbalance. Normal cells follow the homeostasis when they proliferate and cancer cells do not. This work deals a model consisting of three reaction–diffusion equations representing in vitro interaction between two drugs. One drug inhibits proliferation of cancerous cells, and the other destroys these cells. The growth of in-vitro cancer cells has been studied using two numerical methods: the Predictor–Corrector and the Operator splitting method. A stability analysis of the model is performed with and without diffusion.

Original languageEnglish
Pages (from-to)1861-1878
Number of pages18
JournalInternational Journal of Applied and Computational Mathematics
Volume3
Issue number3
DOIs
StatePublished - 1 Sep 2017
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Operator splitting
  • Stability of reaction–diffusion system
  • Tumor growth

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