TY - JOUR
T1 - A comprehensive narrative review on the significance of hyaluronic acid for dental implantology
AU - Alqutaibi, Ahmed Yaseen
AU - Maher, Nazrah
AU - Mahmood, Anum
AU - Amin, Faiza
AU - Mustafa, Ghulam Irtiza
AU - Kumar, Naresh
AU - Zafar, Muhammad Sohail
N1 - Publisher Copyright:
© 2026 The Author(s). Published by MJS Publishing on behalf of Acta Odontologica Scandinavica Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, with the condition of proper attribution to the original work.
PY - 2026/1
Y1 - 2026/1
N2 - Dental implants have significantly advanced the scope of oral health care and practices, providing a stable and durable solution for replacing missing teeth. Essential maintenance practices, including regular oral hygiene and professional monitoring, are imperative to prevent complications such as peri-implant diseases, which can compromise implant integrity. Supplementary agents, including hyaluronic acid (HA), have been shown to enhance healing and integration. HA is recognised for its moisture-retaining properties, its promotion of wound healing, its reduction of inflammation, and its facilitation of tissue integration. The extensive therapeutic applications of HA in dental implant therapy are due to its biocompatibility and regulatory influences on cellular behaviour, which render HA a valuable adjunct to implant success, particularly concerning soft and hard tissue integration around the implants. The present study aims to explore the potential applications of HA in dental implantology, including the modification of implant surfaces, the promotion of soft tissue healing around the implants, and the management of peri-implant diseases, such as mucositis and peri-implantitis. In addition, this study explores the role of HA in alveolar bone regeneration, particularly through alveolar ridge augmentation and preservation processes, as well as more advanced techniques such as tissue engineering, as the primary requirement for successful implant placement is sufficient bone width and depth. HA promotes osseointegration, increases osteogenesis, and helps treat peri-implant conditions such as mucositis and peri-implantitis. Implant biocompatibility, hydrophilicity, and bacterial adhesion resistance are all enhanced by HA coatings, which facilitate improved peri-implant bone and soft tissue healing. Stability and healing properties of HA can be increased by combining it with other biomaterials. Future studies should focus on enhancing HA’s mechanical properties, improving long-term bioactivity, and investigating synergistic biomaterial combinations; clinical trials are required to fully understand its potential in implant dentistry.
AB - Dental implants have significantly advanced the scope of oral health care and practices, providing a stable and durable solution for replacing missing teeth. Essential maintenance practices, including regular oral hygiene and professional monitoring, are imperative to prevent complications such as peri-implant diseases, which can compromise implant integrity. Supplementary agents, including hyaluronic acid (HA), have been shown to enhance healing and integration. HA is recognised for its moisture-retaining properties, its promotion of wound healing, its reduction of inflammation, and its facilitation of tissue integration. The extensive therapeutic applications of HA in dental implant therapy are due to its biocompatibility and regulatory influences on cellular behaviour, which render HA a valuable adjunct to implant success, particularly concerning soft and hard tissue integration around the implants. The present study aims to explore the potential applications of HA in dental implantology, including the modification of implant surfaces, the promotion of soft tissue healing around the implants, and the management of peri-implant diseases, such as mucositis and peri-implantitis. In addition, this study explores the role of HA in alveolar bone regeneration, particularly through alveolar ridge augmentation and preservation processes, as well as more advanced techniques such as tissue engineering, as the primary requirement for successful implant placement is sufficient bone width and depth. HA promotes osseointegration, increases osteogenesis, and helps treat peri-implant conditions such as mucositis and peri-implantitis. Implant biocompatibility, hydrophilicity, and bacterial adhesion resistance are all enhanced by HA coatings, which facilitate improved peri-implant bone and soft tissue healing. Stability and healing properties of HA can be increased by combining it with other biomaterials. Future studies should focus on enhancing HA’s mechanical properties, improving long-term bioactivity, and investigating synergistic biomaterial combinations; clinical trials are required to fully understand its potential in implant dentistry.
KW - Biomolecules
KW - biomaterials
KW - coatings
KW - prosthodontics
KW - scaffold
UR - https://www.scopus.com/pages/publications/105039529824
U2 - 10.2340/biid.v13.45432
DO - 10.2340/biid.v13.45432
M3 - Review article
AN - SCOPUS:105039529824
SN - 2641-5275
VL - 13
SP - 88
EP - 108
JO - Biomaterial Investigations in Dentistry
JF - Biomaterial Investigations in Dentistry
ER -