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A chaos study of tumor and effector cells in fractional tumor-immune model for cancer treatment

  • Sunil Kumar
  • , Ajay Kumar
  • , Bessem Samet
  • , J. F. Gómez-Aguilar
  • , M. S. Osman
  • National Institute of Technology Jamshedpur
  • King Saud University
  • Tecnológico Nacional de México, Mexico City
  • Cairo University
  • Umm Al-Qura University

Research output: Contribution to journalArticlepeer-review

208 Scopus citations

Abstract

A tumor is most dangerous disease of medical science which is a mass or lumps of tissue that's formed by an accumulation of abnormal cells. A famous fractional tumor-immune model is interpreting the dynamics of tumor and effector cells. In this work, we provide a comparative and chaotic study of tumor and effector cells through fractional tumor-immune dynamical model. A new arbitrary operator based on the Mittag-Leffler law is assumed for this study. Again, we examine the interactions among distinct tumor cell inhabitants and immune structure through a model of real world problem of medical science. We First investigate the dynamical effect of the activation of the effector immune and tumor cells by using Adams-Bashforth-Moulton and Toufik-Atangana methods. Furthermore, this paper analyses the existence and uniqueness of given tumor-immune model of arbitrary order. Further, we have examined the dynamical behaviors of the fractional tumor-immunne model and obtained results are compared with exiting results by other methods. Numerical simulations are executed by Adams-Bashforth-Moulton and Toufik-Atangana methods using popular Atangana-Baleanu fractional derivative. Our obtained results will be useful for biologists to the treatment of cancer disease.

Original languageEnglish
Article number110321
JournalChaos, Solitons and Fractals
Volume141
DOIs
StatePublished - Dec 2020
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • AB derivative
  • Adams-Bashforth-Moulton method
  • Existence and uniqueness results
  • Fractional tumor-immune model
  • Toufik-Atangana method

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